Evaluation Of Salmonella-Typhimurium Strains Harboring Defined Mutations In Htra And Aroa In The Murine Salmonellosis Model

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dc.contributor.author Chatfield, S
dc.contributor.author Strahan, K
dc.contributor.author Pickard, D
dc.contributor.author Charles, IG
dc.contributor.author Hormaeche, C
dc.contributor.author Dougan, G
dc.date.accessioned 2011-02-07T06:24:01Z
dc.date.issued 1992-01
dc.identifier.citation Microbial Pathogenesis, 1992, 12 (2), pp. 145 - 151
dc.identifier.issn 0882-4010
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/13703
dc.description.abstract Derivatives of the mouse-virulent Salmonella typhimurium strain SL1344 were constructed harbouring defined mutations in htrA, aroA or htrA aroA combined. When administered orally or intravenously to BALB/c mice, all the mutants were found to be highly attenuated. All mutants were able to confer significant protection against lethal challenge with SL1344 after a single oral dose of live organisms. SL1344 htrA mutants persisted in livers and spleens at a lower level than SL1344 aroA mutants after intravenous administration. SL1344 htrA aroA mutants persisted at an even lower level and were cleared from the livers and spleens of mice within 21 days of intravenous administration. Thus htrA and htrA aroA mutants can be considered as potential oral vaccines against salmonellosis.
dc.format Yes
dc.publisher Academic Press Ltd
dc.relation.isbasedon 10.1016/0882-4010(92)90117-7
dc.title Evaluation Of Salmonella-Typhimurium Strains Harboring Defined Mutations In Htra And Aroa In The Murine Salmonellosis Model
dc.type Journal Article
dc.parent Microbial Pathogenesis
dc.journal.volume 2
dc.journal.volume 12
dc.journal.number 2 en_US
dc.publocation London, UK en_US
dc.identifier.startpage 145 en_US
dc.identifier.endpage 151 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 1108 Medical Microbiology
dc.personcode 109028
dc.percentage 100 en_US
dc.classification.name Medical Microbiology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity ISI:A1992HM96300007 en_US
dc.location.activity ISI:A1992HM96300007
dc.location.activity ISI:A1992HM96300007
dc.description.keywords vaccines; Salmonella; mutants; heat-shock en_US
dc.description.keywords vaccines
dc.description.keywords Salmonella
dc.description.keywords mutants
dc.description.keywords heat-shock
dc.description.keywords vaccines
dc.description.keywords Salmonella
dc.description.keywords mutants
dc.description.keywords heat-shock
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - i3


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