Nucleotide-Sequence Analysis Of The Cat Gene Of Proteus-Mirabilis - Comparison With The Type-I (Tn9) Cat Gene

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Show simple item record Charles, IG Keyte, J Shaw, W 2011-02-07T06:24:46Z 1985-01
dc.identifier.citation Journal Of Bacteriology, 1985, 164 (1), pp. 123 - 129
dc.identifier.issn 0021-9193
dc.identifier.other C1UNSUBMIT en_US
dc.description.abstract In Proteus mirabilis PM13 chloramphenicol resistance is mediated by the cat gene, a single copy of which is present in both resistant and sensitive isolates and which reverts at a high frequency. RNA measurements show an about 8.5-fold increase in cat-specific mRNA in cells expressing the resistance phenotype as compared with those which are sensitive to chloramphenicol. DNA sequence analysis has revealed a high degree of homology between the P. mirabilis cat gene and the type I cat variant (Tn9), 76% at the amino acid level and 73% when nucleotides in the coding sequence are compared. Sequence homology between the strain PM13 cat variant and Tn9 cat was not apparent however in the 5' and 3' flanking regions. Segments of near identity were seen when the upstream sequence of the cat of P. mirabilis was compared with the 5' regions of the Salmonella typhimurium flagellin genes HI and H2, which are alternately expressed by a flip-flop control mechanism involving an invertible promoter and a trans-acting product.
dc.format Yes
dc.publisher Amer Soc Microbiology
dc.title Nucleotide-Sequence Analysis Of The Cat Gene Of Proteus-Mirabilis - Comparison With The Type-I (Tn9) Cat Gene
dc.type Journal Article
dc.parent Journal Of Bacteriology
dc.journal.volume 1
dc.journal.volume 164
dc.journal.number 1 en_US
dc.publocation Washington en_US
dc.identifier.startpage 123 en_US
dc.identifier.endpage 129 en_US SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 1108 Medical Microbiology
dc.personcode 109028
dc.percentage 100 en_US Medical Microbiology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US en_US
dc.location.activity ISI:A1985ASA7400018 en_US
dc.location.activity ISI:A1985ASA7400018
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - i3
utslib.copyright.status Closed Access 2015-04-15 12:17:09.805752+10
pubs.consider-herdc false
utslib.collection.history Closed (ID: 3)
utslib.collection.history Uncategorised (ID: 363)

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