Inducible Nitric Oxide Synthase Polymorphism And Fatal Cerebral Malaria

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dc.contributor.author Burgner, D
dc.contributor.author Xu, W
dc.contributor.author Rockett, K
dc.contributor.author Gravenor, ME
dc.contributor.author Charles, IG
dc.contributor.author Hill, AL
dc.contributor.author Kwiatkowski, D
dc.date.accessioned 2011-02-07T06:29:14Z
dc.date.issued 1998-01
dc.identifier.citation The Lancet, 1998, 352 (9135), pp. 1193 - 1194
dc.identifier.issn 0140-6736
dc.identifier.other C4 en_US
dc.identifier.uri http://hdl.handle.net/10453/14178
dc.description.abstract There has been much speculation about the part played by nitric oxide (NO) in malaria, both as an antiparasitic agent and as a potential cause of neurosuppression leading to cerebral malaria.[1] and [2] Investigation is hampered by difficulty in estimating in-vivo production of NO, but genetic studies provide a potential means of examining the relation between NO production and disease outcome. A report from Gabon suggests that a single nucleotide polymorphism in the inducible nitric oxide synthase (NOS2) promoter is associated with protection from all forms of severe malaria, including susceptibility to reinfection.3 We present data from The Gambia suggesting that a similar region of the NOS2 gene encodes a susceptibility determinant for fatal cerebral malaria.
dc.format Yes
dc.publisher Lancet Ltd
dc.relation.isbasedon 10.1016/S0140-6736(05)60531-4
dc.subject NA, General & Internal Medicine
dc.subject NA; General & Internal Medicine
dc.title Inducible Nitric Oxide Synthase Polymorphism And Fatal Cerebral Malaria
dc.type Journal Article
dc.parent The Lancet
dc.journal.volume 9135
dc.journal.volume 352
dc.journal.number 9135 en_US
dc.publocation London, UK en_US
dc.identifier.startpage 1193 en_US
dc.identifier.endpage 1194 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 1108 Medical Microbiology
dc.personcode 0000060262 en_US
dc.personcode 0000020080 en_US
dc.personcode 0000060263 en_US
dc.personcode 995699 en_US
dc.personcode 109028 en_US
dc.personcode 104610 en_US
dc.personcode 0000060264 en_US
dc.percentage 100 en_US
dc.classification.name Medical Microbiology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity ISI:000076415400016 en_US
dc.location.activity ISI:000076415400016
dc.description.keywords NA en_US
dc.description.keywords NA
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/DVC (Teaching and Learning)
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - i3


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