Quantitative imaging of element spatial distribution in the brain section of a mouse model of Alzheimer's disease using synchrotron radiation X-ray fluorescence analysis

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dc.contributor.author Wang, H
dc.contributor.author Wang, M
dc.contributor.author Wang, B
dc.contributor.author Meng, X
dc.contributor.author Wang, Y
dc.contributor.author Li, M
dc.contributor.author Feng, W
dc.contributor.author Zhao, Y
dc.contributor.author Chai, Z
dc.date.accessioned 2012-02-02T05:13:10Z
dc.date.issued 2010-01
dc.identifier.citation Journal of Analytical Atomic Spectrometry, 2010, 25 (3), pp. 328 - 333
dc.identifier.issn 0267-9477
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/14618
dc.description.abstract A method for quantitative imaging of trace elements in sections of bio-tissues using synchrotron radiation microbeam X-ray fluorescence (SR-µXRF) analysis was developed. The Compton scattering in the SR-µXRFspectrum was utilized as an internal standard to compensate the differences in thickness and density of thin bio-tissue sections. The ratios of element sensitivities to Compton scattering peak obtained from two matrix-matched standard reference materials were used for the calculation of the concentrations of metals in a brain section. The concentrations of Ca, Fe, Cu and Zn in the standard reference material (GBW 08551, pig liver) determined by this method were in good agreement with the certified values. The detection limits of Ca, Fe, Cu and Zn at 2 s detection were 1.15, 0.53, 0.21, and 0.20 µg g-1, respectively. The method has been successfully applied in accurate and precise imaging of the element variations in the brain section of a transgenic mouse model of Alzheimer's disease.
dc.publisher Royal Society of Chemistry
dc.relation.isbasedon 10.1039/b921201a
dc.title Quantitative imaging of element spatial distribution in the brain section of a mouse model of Alzheimer's disease using synchrotron radiation X-ray fluorescence analysis
dc.type Journal Article
dc.description.version Published
dc.parent Journal of Analytical Atomic Spectrometry
dc.journal.volume 3
dc.journal.volume 25
dc.journal.number 3 en_US
dc.publocation Cambridge, UK en_US
dc.identifier.startpage 328 en_US
dc.identifier.endpage 333 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 0306 Physical Chemistry (Incl. Structural)
dc.for 0301 Analytical Chemistry
dc.personcode 112014
dc.percentage 50 en_US
dc.classification.name Analytical Chemistry en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords NA en_US
dc.description.keywords Science & Technology
dc.description.keywords Physical Sciences
dc.description.keywords Optics
dc.description.keywords OPTICS
dc.description.keywords LASER
dc.description.keywords SLAB
dc.description.keywords NANOCAVITY
dc.description.keywords OPERATION
dc.description.keywords DOT
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
utslib.collection.history Closed (ID: 3)

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