For a left-continuous random walk, absorbing at 0, the joint distribution of the maximum and time to absorption is derived. A description of the tails of the distributions and a conditional limit theorem are obtained for ...
Abstract: The use of the likelihood ratio statistic in testing the goodness of fit of the exploratory factor model has no formal justification when, as is often the case in practice, the usual regularity conditions are not ...
Appropriate technology plays an important part in third world development. The most appropriate technology may not be the simplest technology available, nor must it consist of simple mechanical devices. How can physics help?
Assuminga smooth trendp lus independente rrorm odel fort he environmentael ffects in the yields of a fieldp lot experiment,le ast squares smoothingm ethodsa re developed to estimate both the treatmente ffectsa nd the unknown ...
Conditions for the validityo f the Hoel-Walburga nd Peto tests, which compare dose groups with respect to tumour prevalence,a re replaced by a more generalc ondition, representativenesAs. large carcinogenicityex perimentp ...
Carcinogenicity experiments may be analysed by a simple comparison of the control and exposed groups with respect to the proportions of observed tumors amongst dead animals, when longevity is identical in control and exposed ...
We present and discuss several methods for analyzing rodent tumorigenicity experiments. Two approaches are based on the age and tumor status (present/absent) of each animal at the time of death, and assume either that the ...
The Mantel-Haenszel test provides a straightforward method to combine results from several clinical trials when only summary information, such as the proportion of deaths, is available for each trial. More efficient tests, ...
Finkelstein, DM; Ryan, LM(Wiley for the Royal Statistical Society, 1987-01)
Rodent tumorigenicity experiments are conducted to determine whether a particular substance accelerates tumour development. The association between exposure to this substance and the risk of tumour development can be ...
In a general estimation problem, the deviance function generates statistics that are similar to squared standardized residuals. A deviance-based M estimator (DBME) is defined as an adaptively weighted maximum-likelihood ...
Of 86 patients entered in an Eastern Cooperative Oncology Group (ECOG) random Phase II study of mitoxantrone (DHAD) and cisplatin (DDP) in primary liver cancer, 69 were eligible. Nine of the 13 ineligible patients were ...
Associations between patient characteristics and survival were inves tigated in 432 patients with hepatocellular carcinoma. Those patients were prospective!}' studied by the Eastern Cooperative Oncology Group, and each had ...
Cnaan, A; Ryan, LM(John Wiley & Sons Ltd., 1989-01)
Clinicians often wish to use data from clinical trials or hospital databases to study disease natural history. Of particular interest are estimated survival and prognostic factors. In this context, it may be appropriate ...