Acute toxicity of nano- and micro-scale zinc powder in healthy adult mice

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dc.contributor.author Wang, B
dc.contributor.author Feng, W
dc.contributor.author Wang, T
dc.contributor.author Jia, G
dc.contributor.author Wang, M
dc.contributor.author Shi, J
dc.contributor.author Zhang, F
dc.contributor.author Zhao, Y
dc.contributor.author Chai, Z
dc.date.accessioned 2012-02-02T06:36:22Z
dc.date.issued 2006-01
dc.identifier.citation Toxicology Letters, 2006, 161 pp. 115 - 123
dc.identifier.issn 0378-4274
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/14781
dc.description.abstract The purpose of this study is to evaluate the acute toxicity of oral exposure to nanoscale zinc powder in mice. The healthy adult male and female mice were gastrointestinally administered at a dose of 5 g/kg body weight with two size particles, nanoscale zinc (N-Zn) and microscale zinc (M-Zn) powder, while one group mice treated with sodium carboxy methyl cellulose was used as the control. The symptoms and mortality after zinc powder treatment were recorded. The effects of particles on the blood-element, the serum biochemical level and the blood coagulation were studied after 2 weeks of administration. The organs were collected for histopathological examination. The N-Zn treated mice showed more severe symptoms of lethargy, vomiting and diarrhea in the beginning days than the M-Zn mice. Deaths of two mice occurred in the N-Zn group after the first week of treatment. The mortalities were confirmed by intestinal obstruction of the nanoscale zinc aggregation. The biochemical liver function tests of serum showed significantly elevated ALT, AST, ALP, and LDH in the M-Zn mice and ALT, ALP, and LDH in the N-Zn mice compared with the controls (P < 0.05), which indicated that the liver damage was probably induced by both micro- and nano-scale zinc powders. The clinical changes were observed in the two treated group mice as well.
dc.publisher Elsevier B.V.
dc.relation.isbasedon 10.1016/j.toxlet.2005.08.007
dc.title Acute toxicity of nano- and micro-scale zinc powder in healthy adult mice
dc.type Journal Article
dc.parent Toxicology Letters
dc.journal.volume 161
dc.journal.number en_US
dc.publocation United Kingdom, Netherlands en_US
dc.identifier.startpage 115 en_US
dc.identifier.endpage 123 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 0502 Environmental Science and Management
dc.personcode 112014
dc.percentage 100 en_US
dc.classification.name Environmental Science and Management en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.location.activity ISI:000223482300010
dc.description.keywords Acute toxicity; Nanoscale zinc powder; Microscale zinc powder; Mice en_US
dc.description.keywords linear fractional transformation (LFT)
dc.description.keywords linear matrix inequality (LMI)
dc.description.keywords nonlinear fractional transformation (NFT)
dc.description.keywords Acute toxicity
dc.description.keywords Nanoscale zinc powder
dc.description.keywords Microscale zinc powder
dc.description.keywords Mice
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
utslib.collection.history Uncategorised (ID: 363)
utslib.collection.history Closed (ID: 3)


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