Dysregulation of miRNA 181b in the temporal cortex in schizophrenia.

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dc.contributor.author Beveridge, NJ
dc.contributor.author Tooney, PA
dc.contributor.author Carroll, AP
dc.contributor.author Gardiner, E
dc.contributor.author Bowden, N
dc.contributor.author Scott, RJ
dc.contributor.author Tran, N
dc.contributor.author Dedova, I
dc.contributor.author Cairns, MJ
dc.date.accessioned 2012-02-02T07:13:37Z
dc.date.issued 2008-04
dc.identifier.citation Human molecular genetics, 2008, 17 (8), pp. 1156 - 1168
dc.identifier.issn 0964-6906
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/14854
dc.description.abstract Analysis of global microRNA (miRNA) expression in postmortem cortical grey matter from the superior temporal gyrus, revealed significant up-regulation of miR-181b expression in schizophrenia. This finding was supported by quantitative real-time RT-PCR analysis of miRNA expression in a cohort of 21 matched pairs of schizophrenia and non-psychiatric controls. The implications of this finding are substantial, as this miRNA is predicted to regulate many target genes with potential significance to the development of schizophrenia. They include the calcium sensor gene visinin-like 1 (VSNL1) and the ionotropic AMPA glutamate receptor subunit (GRIA2), which were found to be down-regulated in the same cortical tissue from the schizophrenia group. Both of these genes were also suppressed in miR-181b transfected cells and shown to contain functional miR-181b miRNA recognition elements by reporter gene assay. This study suggests altered miRNA levels could be a significant factor in the dysregulation of cortical gene expression in schizophrenia.
dc.format Print-Electronic
dc.language eng
dc.relation.isbasedon 10.1093/hmg/ddn005
dc.title Dysregulation of miRNA 181b in the temporal cortex in schizophrenia.
dc.type Journal Article
dc.parent Human molecular genetics
dc.journal.volume 8
dc.journal.volume 17
dc.journal.number 8 en_US
dc.publocation Oxford en_US
dc.identifier.startpage 1156 en_US
dc.identifier.endpage 1168 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 0601 Biochemistry and Cell Biology
dc.personcode 109012
dc.percentage 100 en_US
dc.classification.name Biochemistry and Cell Biology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity ISI:000254708200010 en_US
dc.location.activity England
dc.description.keywords Humans
dc.description.keywords Cerebral Cortex
dc.description.keywords Temporal Lobe
dc.description.keywords Cell Line
dc.description.keywords MicroRNAs
dc.description.keywords Receptors, AMPA
dc.description.keywords Case-Control Studies
dc.description.keywords Transfection
dc.description.keywords Schizophrenia
dc.description.keywords Gene Expression Regulation
dc.description.keywords Neurocalcin
dc.description.keywords Adult
dc.description.keywords Aged
dc.description.keywords Middle Aged
dc.description.keywords Female
dc.description.keywords Male
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group /University of Technology Sydney/Strength - Health Technologies
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
pubs.consider-herdc false
utslib.collection.history Uncategorised (ID: 363)
utslib.collection.history Closed (ID: 3)


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