Alzheimer's Abeta fused to green fluorescent protein induces growth stress and a heat shock response

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Show simple item record Caine, J Sankovich, S Antony, H Waddington, L Macreadie, PI Varghese, J Macreadie, IG 2012-02-02T07:15:39Z 2007-01
dc.identifier.citation FEMS Yeast Research, 2007, 7 (8), pp. 1230 - 1236
dc.identifier.issn 1567-1356
dc.identifier.other C1UNSUBMIT en_US
dc.description.abstract The 42 amino acid Alzheimer's A beta peptide is involved in the progression of Alzheimer's disease. Here we describe the effects of intracellular A beta, produced through its attachment to either end of a green fluorescent protein, in yeast. Cells producing A beta exhibited a lower growth yield and a heat shock response, showing that A beta fusions promote stress in cells and supporting the notion that intracellular A beta is a toxic molecule. These studies have relevance in understanding the role of A beta in the death of neuronal cells, and indicate that yeast may be a new tractable model system for the screening for inhibitors of the stress caused by A beta.
dc.publisher Wiley-Blackwell Publishing Ltd.
dc.relation.isbasedon 10.1111/j.1567-1364.2007.00285.x
dc.title Alzheimer's Abeta fused to green fluorescent protein induces growth stress and a heat shock response
dc.type Journal Article
dc.parent FEMS Yeast Research
dc.journal.volume 8
dc.journal.volume 7
dc.journal.number 8 en_US
dc.publocation United Kingdom, Netherlands en_US
dc.publocation USA
dc.identifier.startpage 1230 en_US
dc.identifier.endpage 1236 en_US SCI.Environmental Sciences en_US
dc.conference Verified OK en_US
dc.conference ASME International Mechanical Engineering Congress and Exposition
dc.for 0605 Microbiology
dc.personcode 108249
dc.percentage 100 en_US Microbiology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US en_US 2009-11-13
dc.location.activity en_US
dc.location.activity Florida, USA
dc.description.keywords Alzheimer?s disease; protein misfolding; heat shock response; Ab; b amyloid; reactive oxygen specie en_US
dc.description.keywords Decision makers
dc.description.keywords Fuzzy methods
dc.description.keywords Fuzzy theory
dc.description.keywords Labor shortages
dc.description.keywords Major index
dc.description.keywords Master production schedule
dc.description.keywords Overall equipment effectiveness
dc.description.keywords Production line
dc.description.keywords Production plans
dc.description.keywords Production time
dc.description.keywords Decision making
dc.description.keywords Fuzzy logic
dc.description.keywords Mechanical engineering
dc.description.keywords Production
dc.description.keywords Alzheimers disease
dc.description.keywords protein misfolding
dc.description.keywords heat shock response
dc.description.keywords Ab
dc.description.keywords b amyloid
dc.description.keywords reactive oxygen specie
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - C3
utslib.copyright.status Closed Access 2015-04-15 12:17:09.805752+10
utslib.collection.history Closed (ID: 3)

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