Growth inhibition of Candida species and Aspergillus fumigatus by statins

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dc.contributor.author Macreadie, IG
dc.contributor.author Johnson, G
dc.contributor.author Schlosser, T
dc.contributor.author Macreadie, PI
dc.date.accessioned 2012-02-02T08:08:07Z
dc.date.issued 2006-09
dc.identifier.citation FEMS Microbiology Letters, 2006, 262 (1), pp. 9 - 13
dc.identifier.issn 0378-1097
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/14961
dc.description.abstract Statins are a class of drugs widely used for lowering high cholesterol levels through their action on 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme in the synthesis of cholesterol. We studied the effects of two major statins, simvastatin and atorvastatin, on five Candida species and Aspergillus fumigatus. The statins strongly inhibited the growth of all species, except Candida krusei. Supplementation of Candida albicans and A. fumigatus with ergosterol or cholesterol in aerobic culture led to substantial recovery from the inhibition by statins, suggesting specificity of statins for the mevalonate synthesis pathway. Our findings suggest that the statins could have utility as antifungal agents and that fungal colonization could be affected in those on statin therapy. © 2006 CSIRO.
dc.language eng
dc.relation.isbasedon 10.1111/j.1574-6968.2006.00370.x
dc.title Growth inhibition of Candida species and Aspergillus fumigatus by statins
dc.type Journal Article
dc.description.version Published
dc.parent FEMS Microbiology Letters
dc.journal.volume 1
dc.journal.volume 262
dc.journal.number 1 en_US
dc.publocation Amsterdam, Netherlands en_US
dc.identifier.startpage 9 en_US
dc.identifier.endpage 13 en_US
dc.cauo.name SCI.Environmental Sciences en_US
dc.conference Verified OK en_US
dc.for 0605 Microbiology
dc.personcode 108249
dc.percentage 100 en_US
dc.classification.name Microbiology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords Antifungal
dc.description.keywords Atorvastatin
dc.description.keywords Cholesterol
dc.description.keywords Ergosterol
dc.description.keywords HMG-CoA reductase inhibition
dc.description.keywords Simvastatin
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - C3
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
pubs.consider-herdc false
utslib.collection.history Closed (ID: 3)
utslib.collection.history Uncategorised (ID: 363)


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