Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study

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dc.contributor.author Chowdhury, PR
dc.contributor.author Ingold, A
dc.contributor.author Vanegas, N
dc.contributor.author Martínez, E
dc.contributor.author Merlino, J
dc.contributor.author Merkier, AK
dc.contributor.author Castro, M
dc.contributor.author Rocha, GG
dc.contributor.author Borthagaray, G
dc.contributor.author Centrón, D
dc.contributor.author Toledo, HB
dc.contributor.author Márquez, CM
dc.contributor.author Stokes, HW
dc.date.accessioned 2012-02-02T08:21:22Z
dc.date.issued 2011-07
dc.identifier.citation Antimicrobial Agents and Chemotherapy, 2011, 55 (7), pp. 3140 - 3149
dc.identifier.issn 0066-4804
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/14987
dc.description.abstract A comparative genetic analysis of 42 clinical Klebsiella pneumoniae isolates, resistant to two or more antibiotics belonging to the broad-spectrum β-lactam group, sourced from Sydney, Australia, and three South American countries is presented. The study focuses on the genetic contexts of class 1 integrons, mobilizable genetic elements best known for their role in the rapid evolution of antibiotic resistance among Gram-negative pathogens. It was found that the class 1 integrons in this cohort were located in a number of different genetic contexts with clear regional differences. In Sydney, IS26-associated Tn21-like transposons on IncL/M plasmids contribute greatly to the dispersal of integron-associated multiple-drug-resistant (MDR) loci. In contrast, in the South American countries, Tn1696-like transposons on an IncA/C plasmid(s) appeared to be disseminating a characteristic MDR region. A range of mobile genetic elements is clearly being recruited by clinically important mobile class 1 integrons, and these elements appear to be becoming more common with time. This in turn is driving the evolution of complex and laterally mobile MDR units and may further complicate antibiotic therapy. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
dc.language eng
dc.relation.isbasedon 10.1128/AAC.01529-10
dc.title Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study
dc.type Journal Article
dc.description.version Published
dc.parent Antimicrobial Agents and Chemotherapy
dc.journal.volume 7
dc.journal.volume 55
dc.journal.number 7 en_US
dc.publocation United States en_US
dc.identifier.startpage 3140 en_US
dc.identifier.endpage 3149 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 0605 Microbiology
dc.personcode 105741
dc.personcode 105993
dc.personcode 110478
dc.percentage 100 en_US
dc.classification.name Microbiology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - i3
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
pubs.consider-herdc true
utslib.collection.history Closed (ID: 3)


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