Chasing the golden egg: Vaccination against poultry coccidiosis

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Show simple item record Sharman, PA Smith, NC Wallach, MG Katrib, M 2012-02-02T08:39:46Z 2010
dc.identifier.citation Parasite Immunology, 2010, 32 (8), pp. 590 - 598
dc.identifier.issn 0141-9838
dc.identifier.other C1UNSUBMIT en_US
dc.description.abstract Eimeria species, of the Phylum Apicomplexa, cause the disease coccidiosis in poultry, resulting in severe economic losses every year. Transmission of the disease is via the faecal-oral route, and is facilitated by intensive rearing conditions in the poultry industry. Additionally, Eimeria has developed drug resistance against most anticoccidials used today, which, along with the public demand for chemical free meat, has lead to the requirement for an effective vaccine strategy. This review focuses on the history and current status of anticoccidial vaccines, and our work in developing the transmission-blocking vaccine, CoxAbic® (Netanya, Israel). The vaccine is composed of affinity-purified antigens from the wall-forming bodies of macrogametocytes of Eimeria maxima, which are proteolytically processed and cross-linked via tyrosine residues to form the environmentally resistant oocyst wall. The vaccine is delivered via maternal immunization, where vaccination of laying hens leads to protection of broiler offspring. It has been extensively tested for efficacy and safety in field trials conducted in five countries and involving over 60 million offspring chickens from immunized hens and is currently the only subunit vaccine against any protozoan parasite to reach the marketplace. © 2010 Blackwell Publishing Ltd.
dc.language eng
dc.publisher Blackwell Publishing Ltd
dc.relation.isbasedon 10.1111/j.1365-3024.2010.01209.x
dc.title Chasing the golden egg: Vaccination against poultry coccidiosis
dc.type Journal Article
dc.description.version Published
dc.parent Parasite Immunology
dc.journal.volume 8
dc.journal.volume 32
dc.journal.number 8 en_US
dc.publocation UK en_US
dc.publocation Hong Kong
dc.identifier.startpage 590 en_US
dc.identifier.endpage 598 en_US SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.conference Asia Pacific Vibration Conference
dc.for 0707 Veterinary Sciences
dc.personcode 960087
dc.personcode 021128
dc.personcode 044726
dc.percentage 100 en_US Veterinary Sciences en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US en_US 2011-12-05
dc.location.activity en_US
dc.location.activity The Hong Kong Polytechnic University, Hong Kong
dc.description.keywords Apicomplexa
dc.description.keywords Eimeria
dc.description.keywords macrogamete
dc.description.keywords oocyst wall
dc.description.keywords vaccine
dc.description.keywords wall-forming bodies
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - i3
utslib.copyright.status Closed Access 2015-04-15 12:17:09.805752+10
pubs.consider-herdc false
utslib.collection.history Uncategorised (ID: 363)
utslib.collection.history Closed (ID: 3)
utslib.collection.history Closed (ID: 3)

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