Low Thymine Content in PINK1 mRNAs and Insights into Parkinson's disease

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dc.contributor.author Anandagopu, P
dc.contributor.author Rashid, S
dc.contributor.author Li, J
dc.date.accessioned 2012-02-02T10:11:32Z
dc.date.issued 2010-01
dc.identifier.citation Bioinformation, 2010, 4 (10), pp. 452 - 455
dc.identifier.issn 0973-2063
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/15203
dc.description.abstract Thymine is the only nucleotide base which is changed to uracil upon transcription, leaving mRNA less hydrophobic compared to its DNA counterpart. All the 16 codons that contain uracil (or thymine in gene) as the second nucleotide code for the five large hydrophobic residues (LHRs), namely phenylalanine,v isoleucine, leucine, methionine and valine. Thymine content (i.e. the fraction of XTX codons, where X = A, C, G, or T) in PINK1 mRNA sequences and its relationship with protein stability and function are the focus of this work. This analysis will shed light on PINK1's stability, thus a clue can be provided to understand the mitochondrial dysfunction and the failure of oxidative stress control frequently observed in Parkinson's disease. We obtained the complete PINK1 mRNA sequences of 8 different species. The distributions of XTX codons in different frames are calculated. We observed that the thymine content reached the highest level in the coding frame 1 of the PINK1 mRNA sequence of Bos Taurus (Bt), that is peaked at 27%. Coding frame 1 containing low thymine leads to the reduction in LHRs in the corresponding proteins. Therefore, we conjecture that proteins from the other organisms, including Homo sapiens, lost some of their hydrophobicity and became susceptible to dysfunction. Genes such as PINK1 have reduced thymine in the evolutionary process thereby making their protein products potentially being susceptible to instability and causing disease. Adding more hydrophobic residues (thymine) at appropriate places might help conserve important biological functions.
dc.publisher Biomedical Informatics Publishing Group
dc.title Low Thymine Content in PINK1 mRNAs and Insights into Parkinson's disease
dc.type Journal Article
dc.parent Bioinformation
dc.journal.volume 10
dc.journal.volume 4
dc.journal.number 10 en_US
dc.publocation India en_US
dc.identifier.startpage 452 en_US
dc.identifier.endpage 455 en_US
dc.cauo.name FEIT.Faculty of Engineering & Information Technology en_US
dc.conference Verified OK en_US
dc.for 0899 Other Information and Computing Sciences
dc.personcode 112261
dc.percentage 100 en_US
dc.classification.name Other Information and Computing Sciences en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords thymine distribution, PINK1, sequence analysis, protein stability, frame analysis
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group /University of Technology Sydney/Strength - Health Technologies
utslib.copyright.status Open Access
utslib.copyright.date 2015-04-15 12:23:47.074767+10
pubs.consider-herdc false
utslib.collection.history General (ID: 2)

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