Pharmacokinetics of non-prescription sympathomimetic agents

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dc.contributor.author Chua, SS
dc.contributor.author Benrimoj, SI
dc.contributor.author Trigss, EJ
dc.date.accessioned 2012-02-02T10:58:30Z
dc.date.issued 1989
dc.identifier.citation Biopharmaceutics and Drug Disposition, 1989, 10 (1), pp. 1 - 14
dc.identifier.issn 0142-2782
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/15491
dc.description.abstract The pharmacokinetics of non-prescription sympathomimetic agents are discussed with respect to absorption from the gastrointestinal tract, volumes of distribution, metabolism and renal excretion. Where specific data are not available, postulations are made with inference from the chemical structures of these agents, or from studies with other drugs. No studies on hypertensive patients have been found, but attempts are made to correlate any possible changes in the pharmacokinetics of these sympathomimetic agents to hypertensive patients as a high proportion of the elderly population is hypertensive. Sympathomimetic agents with lesser polar hydroxyl groups, for example, are thought to be more lipophilic and are more readily absorbed from the gastrointestinal tract, have higher volumes of distribution, and are more extensively metabolized. Major metabolic pathways include oxidation, deamination, demethylation, and conjugation. Most of these agents are excreted primarily through the kidneys and due to their basic nature, the rate of excretion is dependent on urinary pHs. Any alteration in kidney functions such as in the aged, is therefore, expected to have some clinical significance on the pharmacokinetics of these agents.
dc.language eng
dc.title Pharmacokinetics of non-prescription sympathomimetic agents
dc.type Journal Article
dc.parent Biopharmaceutics and Drug Disposition
dc.journal.volume 1
dc.journal.volume 10
dc.journal.number 1 en_US
dc.publocation W Sussex en_US
dc.identifier.startpage 1 en_US
dc.identifier.endpage 14 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 1115 Pharmacology and Pharmaceutical Sciences
dc.personcode 111638
dc.percentage 100 en_US
dc.classification.name Pharmacology and Pharmaceutical Sciences en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity ISI:A1989R843100001 en_US
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Graduate School of Health
pubs.organisational-group /University of Technology Sydney/Strength - Health Services and Practice Research
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
pubs.consider-herdc false
utslib.collection.history Closed (ID: 3)


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