Cardiovascular effects of a chlorpheniramine/paracetamol combination in hypertensive patients who were sensitive to the pressor effect of pseudoephedrine

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dc.contributor.author Chua, SS
dc.contributor.author Benrimoj, SI
dc.contributor.author Gordon, RD
dc.contributor.author Williams, G
dc.date.accessioned 2012-02-02T10:59:19Z
dc.date.issued 1991
dc.identifier.citation British Journal of Clinical Pharmacology, 1991, 31 (3), pp. 360 - 362
dc.identifier.issn 0306-5251
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/15529
dc.description.abstract Twelve hypertensive patients who were classified as pseudoephedrine-sensitive in a preliminary trial were selected for further investigation with single doses of pseudoephedrine 60 mg, a combination of chlorpheniramine 4 mg with paracetamol 650 mg and placebo. A double-blind, randomised, crossover study design was followed. Treatment with pseudoephedrine produced significant effects on all the four variables measured (systolic, diastolic and mean arterial blood pressure, and heart rate). Effects of the chlorpheniramine/paracetamol combination were found to be not significantly different from placebo. It was concluded that the combination may be useful as a medication for 'colds' in hypertensive patients, since it does not induce cardiovascular effects such as those observed with pseudoephedrine.
dc.language eng
dc.title Cardiovascular effects of a chlorpheniramine/paracetamol combination in hypertensive patients who were sensitive to the pressor effect of pseudoephedrine
dc.type Journal Article
dc.description.version Published
dc.parent British Journal of Clinical Pharmacology
dc.journal.volume 3
dc.journal.volume 31
dc.journal.number 3 en_US
dc.publocation Oxford en_US
dc.identifier.startpage 360 en_US
dc.identifier.endpage 362 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 1115 Pharmacology and Pharmaceutical Sciences
dc.personcode 111638
dc.percentage 100 en_US
dc.classification.name Pharmacology and Pharmaceutical Sciences en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity ISI:A1991FB73500023 en_US
dc.description.keywords Blood pressure
dc.description.keywords Chlorpheniramine
dc.description.keywords Heart rate
dc.description.keywords Hypertensive patients
dc.description.keywords Paracetamol
dc.description.keywords Pseudoephedrine
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Graduate School of Health
pubs.organisational-group /University of Technology Sydney/Strength - Health Services and Practice Research
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
pubs.consider-herdc false
utslib.collection.history Closed (ID: 3)


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