Oestrogen receptor beta expression in pleomorphic adenomas of the parotid gland.

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dc.contributor.author Wong, MH
dc.contributor.author Dobbins, TA
dc.contributor.author Tseung, J
dc.contributor.author Tran, N
dc.contributor.author Lee, CS
dc.contributor.author O'Brien, CJ
dc.contributor.author Clark, J
dc.contributor.author Rose, BR
dc.date.accessioned 2012-02-02T11:01:20Z
dc.date.issued 2009-09
dc.identifier.citation Journal of clinical pathology, 2009, 62 (9), pp. 789 - 793
dc.identifier.issn 0021-9746
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/15634
dc.description.abstract AIMS: Pleomorphic adenomas of the salivary gland have gender and age distributions suggesting that oestrogen has a causal role. However, oestrogen receptor (ER)alpha is expressed at low levels in normal salivary gland tissues and data from salivary gland tumours are conflicting. There is preliminary evidence that the recently described ERbeta may be the major ER in salivary gland tissue. The aim of this study was to determine the nature and extent of ERbeta expression in pleomorphic adenomas of the salivary gland. METHODS: Pleomorphic adenomas and normal tissues of the parotid gland from 49 patients were tested for ERalpha and ERbeta expression by semiquantitative immunohistochemistry. Associations were sought with patient age and gender. RESULTS: ERalpha and ERbeta expression was localised mainly to the nuclei of ductal cells in normal tissues and the epithelial components in pleomorphic adenomas. Within each tissue and receptor type there were no associations between ER positivity and patient age or gender. ERbeta was expressed in almost twice as many normal tissues and pleomorphic adenomas as ERalpha. Expression of ERbeta was also significantly higher in tumour compared with normal tissues. CONCLUSIONS: This is thought to be the first study of ERbeta in pleomorphic adenomas of the salivary gland. Findings support ERbeta as the major ER in salivary glands, and provide evidence that ERbeta may have a role in the development of pleomorphic adenomas of the salivary gland.
dc.format Print
dc.language eng
dc.relation.isbasedon 10.1136/jcp.2009.065102
dc.title Oestrogen receptor beta expression in pleomorphic adenomas of the parotid gland.
dc.type Journal Article
dc.parent Journal of clinical pathology
dc.journal.volume 9
dc.journal.volume 62
dc.journal.number 9 en_US
dc.publocation London en_US
dc.publocation Leicester, UK
dc.identifier.startpage 789 en_US
dc.identifier.endpage 793 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 1103 Clinical Sciences
dc.personcode 109012
dc.percentage 100 en_US
dc.classification.name Clinical Sciences en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.edition 1
dc.custom en_US
dc.date.activity en_US
dc.location.activity ISI:000270223900005 en_US
dc.location.activity England
dc.description.keywords Salivary-Glands; Breast-Carcinoma; Progesterone-Receptors; Tumors; Gene; Er; Tissue; Identification; Periodontium; Isoforms en_US
dc.description.keywords Adenoma, Pleomorphic
dc.description.keywords Adult
dc.description.keywords Age Factors
dc.description.keywords Estrogen Receptor alpha
dc.description.keywords Estrogen Receptor beta
dc.description.keywords Female
dc.description.keywords Humans
dc.description.keywords Immunoenzyme Techniques
dc.description.keywords Male
dc.description.keywords Middle Aged
dc.description.keywords Neoplasm Proteins
dc.description.keywords Parotid Gland
dc.description.keywords Parotid Neoplasms
dc.description.keywords Sex Factors
dc.description.keywords Parotid Gland
dc.description.keywords Humans
dc.description.keywords Adenoma, Pleomorphic
dc.description.keywords Parotid Neoplasms
dc.description.keywords Neoplasm Proteins
dc.description.keywords Estrogen Receptor alpha
dc.description.keywords Estrogen Receptor beta
dc.description.keywords Immunoenzyme Techniques
dc.description.keywords Age Factors
dc.description.keywords Sex Factors
dc.description.keywords Adult
dc.description.keywords Middle Aged
dc.description.keywords Female
dc.description.keywords Male
dc.description.keywords Parotid Gland
dc.description.keywords Humans
dc.description.keywords Adenoma, Pleomorphic
dc.description.keywords Parotid Neoplasms
dc.description.keywords Neoplasm Proteins
dc.description.keywords Estrogen Receptor alpha
dc.description.keywords Estrogen Receptor beta
dc.description.keywords Immunoenzyme Techniques
dc.description.keywords Age Factors
dc.description.keywords Sex Factors
dc.description.keywords Adult
dc.description.keywords Middle Aged
dc.description.keywords Female
dc.description.keywords Male
dc.description.keywords Humans
dc.description.keywords Parotid Gland
dc.description.keywords Adenoma, Pleomorphic
dc.description.keywords Parotid Neoplasms
dc.description.keywords Estrogen Receptor alpha
dc.description.keywords Neoplasm Proteins
dc.description.keywords Immunoenzyme Techniques
dc.description.keywords Age Factors
dc.description.keywords Adult
dc.description.keywords Estrogen Receptor beta
dc.description.keywords Middle Aged
dc.description.keywords Sex Factors
dc.description.keywords Female
dc.description.keywords Male
dc.description.keywords Humans
dc.description.keywords Parotid Gland
dc.description.keywords Adenoma, Pleomorphic
dc.description.keywords Parotid Neoplasms
dc.description.keywords Estrogen Receptor alpha
dc.description.keywords Neoplasm Proteins
dc.description.keywords Immunoenzyme Techniques
dc.description.keywords Age Factors
dc.description.keywords Adult
dc.description.keywords Estrogen Receptor beta
dc.description.keywords Middle Aged
dc.description.keywords Sex Factors
dc.description.keywords Female
dc.description.keywords Male
dc.description.keywords Humans
dc.description.keywords Parotid Gland
dc.description.keywords Adenoma, Pleomorphic
dc.description.keywords Parotid Neoplasms
dc.description.keywords Estrogen Receptor alpha
dc.description.keywords Neoplasm Proteins
dc.description.keywords Immunoenzyme Techniques
dc.description.keywords Age Factors
dc.description.keywords Adult
dc.description.keywords Estrogen Receptor beta
dc.description.keywords Middle Aged
dc.description.keywords Sex Factors
dc.description.keywords Female
dc.description.keywords Male
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group /University of Technology Sydney/Strength - Health Technologies


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