Quality of life and survival in the 2 years after surgery for non-small-cell lung cancer

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dc.contributor.author Kenny, PM
dc.contributor.author King, MT
dc.contributor.author Viney, RC
dc.contributor.author Boyer, M
dc.contributor.author Pollicino, C
dc.contributor.author McLean, J
dc.contributor.author Fulham, MJ
dc.contributor.author McCaughan, BC
dc.date.accessioned 2012-02-10T06:09:40Z
dc.date.issued 2008-01
dc.identifier.citation Journal of Clinical Oncology, 2008, 26 (2), pp. 233 - 241
dc.identifier.issn 0732-183X
dc.identifier.other C5 en_US
dc.identifier.uri http://hdl.handle.net/10453/17091
dc.description.abstract Purpose Although surgery for early-stage non-small-cell lung cancer ( NSCLC) is known to have a substantial impact on health-related quality of life (HRQOL), there are few published studies about HRQOL in the longer term. This article examines HRQOL and survival in the 2 years after surgery. Patients and Methods Patients with clinical stage I or II NSCLC (n = 173) completed HRQOL questionnaires before surgery, at discharge, 1 month after surgery, and then every 4 months for 2 years. HRQOL was measured with a generic cancer questionnaire (European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire [ EORTC-QLQ] C30) and a lung cancer-specific questionnaire (EORTC QLQ-LC13). Data were analyzed to examine the impact of surgery and any subsequent therapy, and to describe the trajectories of those who remained disease free at 2 years and those with recurrent cancer diagnosed during follow-up. Results Disease recurred within 2 years for 36% of patients and 2-year survival was 65%. Surgery substantially reduced HRQOL across all dimensions except emotional functioning. HRQOL improved in the 2 years after surgery for patients without disease recurrence, although approximately half continued to experience symptoms and functional limitations. For those with recurrence within 2 years, there was some early postoperative recovery in HRQOL, with subsequent deterioration across most dimensions.
dc.publisher Amer Soc Clinical Oncology
dc.relation.isbasedon 10.1200/JCO.2006.07.7230
dc.title Quality of life and survival in the 2 years after surgery for non-small-cell lung cancer
dc.type Journal Article
dc.description.version Published
dc.parent Journal of Clinical Oncology
dc.journal.volume 2
dc.journal.volume 26
dc.journal.number 2 en_US
dc.publocation USA en_US
dc.identifier.startpage 233 en_US
dc.identifier.endpage 241 en_US
dc.cauo.name BUS.Faculty of Business en_US
dc.conference Verified OK en_US
dc.for 1112 Oncology and Carcinogenesis
dc.personcode 020117
dc.personcode 106668
dc.personcode 020118
dc.percentage 100 en_US
dc.classification.name Oncology and Carcinogenesis en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords NA en_US
dc.description.keywords Science & Technology
dc.description.keywords Life Sciences & Biomedicine
dc.description.keywords Respiratory System
dc.description.keywords RESPIRATORY SYSTEM
dc.description.keywords chronic obstructive pulmonary disease
dc.description.keywords dyspnoea
dc.description.keywords non-invasive positive pressure ventilation
dc.description.keywords respiratory insufficiency
dc.description.keywords systematic
dc.description.keywords review
dc.description.keywords ACUTE RESPIRATORY-FAILURE
dc.description.keywords RANDOMIZED CONTROLLED-TRIALS
dc.description.keywords NASAL VENTILATION
dc.description.keywords BREATHLESSNESS
dc.description.keywords MANAGEMENT
dc.description.keywords COPD
dc.description.keywords STATEMENT
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Business
pubs.organisational-group /University of Technology Sydney/Strength - Health Economics and Research Evaluation
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
utslib.collection.history Closed (ID: 3)
utslib.collection.history Uncategorised (ID: 363)

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