Myxoma T2 protein as a model for poxvirus TNF receptor homologs

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Show simple item record McFadden, GI Schreiber, M Sedger, LM
dc.contributor.editor NA 2012-10-12T03:33:29Z 1997-01
dc.identifier.citation Journal of Neuroimmunology, 1997, 72 pp. 2 - 119
dc.identifier.issn 0165-5728
dc.identifier.other C1UNSUBMIT en_US
dc.description.abstract Many poxviruses encode a plethora of immunomodulatory proteins, including homologs of cellular cytokine receptors. These receptor mimics, also referred to as viroceptors, are believed to function by binding and sequestering host cytokines thus preventing their signaling cascade prior to receptor engagement. The M-T2 protein of myxoma virus is a TNF receptor homolog that has two distinct activities: the secreted dimeric M-T2 protein binds and inhibits TNF alpha while the intracellular version permits myxoma virus replication in infected T-lymphocytes by blocking the cellular apoptosis response to the virus infection. Studies with M-T2 mutants reveal that distinct protein domains mediate these two anti-immune properties of this protein.
dc.format Scott McWhirter
dc.publisher Elsevier Science
dc.title Myxoma T2 protein as a model for poxvirus TNF receptor homologs
dc.type Journal Article
dc.parent Journal of Neuroimmunology
dc.journal.volume 72
dc.journal.number en_US
dc.publocation Netherlands en_US
dc.identifier.startpage 2 en_US
dc.identifier.endpage 119 en_US SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 060103 Cell Development, Proliferation and Death
dc.for 060506 Virology
dc.personcode 102397
dc.percentage 60 en_US Virology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom International TNF Congress en_US 19960508 en_US
dc.location.activity Rhodes, Greece en_US
dc.description.keywords tumor necrosis factor; viroceptor; virokine; myxomatosis; vaccinia; apoptosis en_US
dc.description.keywords tumor necrosis factor
dc.description.keywords viroceptor
dc.description.keywords virokine
dc.description.keywords myxomatosis
dc.description.keywords vaccinia
dc.description.keywords apoptosis
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
utslib.copyright.status Closed Access 2015-04-15 12:17:09.805752+10
utslib.collection.history Closed (ID: 3)

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