Integron associated mobile genes: Just a collection of plug in apps or essential components of cell network hardware?

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dc.contributor.author Labbate, M
dc.contributor.author Boucher, Y
dc.contributor.author Luu, I
dc.contributor.author Chowdhury, PR
dc.contributor.author Stokes, HW
dc.date.accessioned 2012-10-12T03:33:31Z
dc.date.issued 2012-01
dc.identifier.citation Mobile genetic elements, 2012, 2 (1), pp. 13 - 18
dc.identifier.issn 2159-2543
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/18182
dc.description.abstract Lateral gene transfer (LGT) impacts on the evolution of prokaryotes in both the short and long-term. The short-term impacts of mobilized genes are a concern to humans since LGT explains the global rise of multi drug resistant pathogens seen in the past 70 years. However, LGT has been a feature of prokaryotes from the earliest days of their existence and the concept of a bifurcating tree of life is not entirely applicable to prokaryotes since most genes in extant prokaryotic genomes have probably been acquired from other lineages. Successful transfer and maintenance of a gene in a new host is understandable if it acts independently of cell networks and confers an advantage. Antibiotic resistance provides an example of this whereby a gene can be advantageous in virtually any cell across broad species backgrounds. In a longer evolutionary context however laterally transferred genes can be assimilated into even essential cell networks. How this happens is not well understood and we discuss recent work that identifies a mobile gene, unique to a cell lineage, which is detrimental to the cell when lost. We also present some additional data and believe our emerging model will be helpful in understanding how mobile genes integrate into cell networks.
dc.format Print
dc.language eng
dc.relation.hasversion Accepted manuscript version en_US
dc.relation.isbasedon 10.4161/mge.19510
dc.relation.isreplacedby 10453/32705
dc.relation.isreplacedby http://hdl.handle.net/10453/32705
dc.subject integron, mobile gene cassette, lateral gene transfer, cell networks, adaptation, Vibrios
dc.title Integron associated mobile genes: Just a collection of plug in apps or essential components of cell network hardware?
dc.type Journal Article
dc.parent Mobile genetic elements
dc.journal.volume 1
dc.journal.volume 2
dc.journal.number 1 en_US
dc.publocation United States en_US
dc.publocation Germany
dc.identifier.startpage 13 en_US
dc.identifier.endpage 18 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 0605 Microbiology
dc.personcode 106011 en_US
dc.personcode 0000073212 en_US
dc.personcode 0000073538 en_US
dc.personcode 105993 en_US
dc.personcode 105741 en_US
dc.percentage 100 en_US
dc.classification.name Microbiology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.edition 1st
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords integron, mobile gene cassette, lateral gene transfer, cell networks, adaptation, Vibrios en_US
dc.staffid en_US
dc.staffid 105741 en_US
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Faculty of Science/School of Medical and Molecular Sciences
pubs.organisational-group /University of Technology Sydney/Strength - i3
utslib.copyright.status Open Access
utslib.copyright.date 2015-04-15 12:23:47.074767+10
utslib.collection.history General (ID: 2)


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