Prescheduling graphic displays for optimal cancer therapies to reveal possible tumor regression or stabilization

DSpace/Manakin Repository

Search OPUS


Advanced Search

Browse

My Account

Show simple item record

dc.contributor.author Thornton, BS
dc.contributor.author Langtry, TN
dc.date.accessioned 2012-10-12T03:33:56Z
dc.date.issued 1988-02
dc.identifier.citation Journal of Medical Systems, 1988, 12 (1), pp. 31 - 41
dc.identifier.issn 0148-5598
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/18345
dc.description.abstract The paper describes an adaptive control approach to the problem of the treatment of solid tumors. The evolution with time t of the state of a tumor is modelled by a two-compartment system, governed by two differential equations forming an autonomous system under therapy control u, {Mathematical expression} where y1 and y2 are the number of proliferating and nonproliferating cells, respectively. The output is analyzed in the phase plane y1y2. The control problem is that of restricting the tumor state to a predetermined region of the plane by selecting a suitable change in therapy control u, e.g., modality and dosage, when the state solution intersects the boundary of this region and the ratio y1/y2 of proliferating to nonproliferating cells is displayed together with an elapsed time scale. Then, consequent selection of a suitable therapeutic sequence may be assisted by the use of a data base as part of an expert system. The process is repeated at each intersection of the prescribed boundary. Such sequences may lead to stabilization of the system through the appearance on a computer display screen of a stable equilibrium point or a limit cycle. © 1988 Plenum Publishing Corporation.
dc.language eng
dc.publisher Kluwer Academic Publishers-Plenum Publishers
dc.relation.isbasedon 10.1007/BF01002374
dc.title Prescheduling graphic displays for optimal cancer therapies to reveal possible tumor regression or stabilization
dc.type Journal Article
dc.parent Journal of Medical Systems
dc.journal.volume 1
dc.journal.volume 12
dc.journal.number 1 en_US
dc.publocation USA en_US
dc.identifier.startpage 31 en_US
dc.identifier.endpage 41 en_US
dc.cauo.name SCI.Mathematical Sciences en_US
dc.conference Verified OK en_US
dc.for 0903 Biomedical Engineering
dc.personcode 994994
dc.personcode 830105
dc.percentage 100 en_US
dc.classification.name Biomedical Engineering en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group /University of Technology Sydney/Faculty of Science
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
pubs.consider-herdc false
utslib.collection.history School of Mathematical Sciences (ID: 340)
utslib.collection.history School of Mathematical Sciences (ID: 340)
utslib.collection.history Closed (ID: 3)
utslib.collection.history Closed (ID: 3)


Files in this item

This item appears in the following Collection(s)

Show simple item record