Early hypothalamic FTO overexpression in response to maternal obesity - potential contribution to postweaning hyperphagia

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dc.contributor.author Caruso, V
dc.contributor.author Chen, H
dc.contributor.author Morris, M
dc.date.accessioned 2012-10-12T03:34:25Z
dc.date.issued 2011-01
dc.identifier.citation Plos One, 2011, 6 (9), pp. 1 - 7
dc.identifier.issn 1932-6203
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/18606
dc.description.abstract Background: Intrauterine and postnatal overnutrition program hyperphagia, adiposity and glucose intolerance in offspring. Single-nucleotide polymorphisms (SNPs) of the fat mass and obesity associated (FTO) gene have been linked to increased risk of obesity. FTO is highly expressed in hypothalamic regions critical for energy balance and hyperphagic phenotypes were linked with FTO SNPs. As nutrition during fetal development can influence the expression of genes involved in metabolic function, we investigated the impact of maternal obesity on FTO. Methods: Female Sprague Dawley rats were exposed to chow or high fat diet (HFD) for 5 weeks before mating, throughout gestation and lactation. On postnatal day 1 (PND1), some litters were adjusted to 3 pups (vs. 12 control) to induce postnatal overnutrition. At PND20, rats were weaned onto chow or HFD for 15 weeks. FTO mRNA expression in the hypothalamus and liver, as well as hepatic markers of lipid metabolism were measured. Results: At weaning, hypothalamic FTO mRNA expression was increased significantly in offspring of obese mothers and FTO was correlated with both visceral and epididymal fat mass (P<0.05); body weight approached significance (P = 0.07). Hepatic FTO and Fatty Acid Synthase mRNA expression were decreased by maternal obesity. At 18 weeks, FTO mRNA expression did not differ between groups; however body weight was significantly correlated with hypothalamic FTO. Postnatal HFD feeding significantly reduced hepatic Carnitine Palmitoyltransferase-1a but did not affect the expression of other hepatic markers investigated. FTO was not affected by chronic HFD feeding. Significance: Maternal obesity significantly impacted FTO expression in both hypothalamus and liver at weaning.
dc.publisher Public Library Science
dc.relation.isbasedon 10.1371/journal.pone.0025261
dc.title Early hypothalamic FTO overexpression in response to maternal obesity - potential contribution to postweaning hyperphagia
dc.type Journal Article
dc.parent Plos One
dc.journal.volume 9
dc.journal.volume 6
dc.journal.number 9 en_US
dc.publocation San Francisco en_US
dc.publocation Melbourne, Australia
dc.identifier.startpage 1 en_US
dc.identifier.endpage en_US
dc.identifier.endpage 7 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.conference Australasian Computing Education Conference
dc.for 1111 Nutrition and Dietetics
dc.personcode 105405
dc.percentage 100 en_US
dc.classification.name Nutrition and Dietetics en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.date.activity 2012-01-30
dc.location.activity en_US
dc.location.activity Melbourne, Australia
dc.description.keywords Gene-Expression Analysis
dc.description.keywords Body-Mass Index
dc.description.keywords Childhood Obesity
dc.description.keywords Mitochondrial Dysfunction
dc.description.keywords Appetite Regulators
dc.description.keywords Adult Obesity
dc.description.keywords Energy-Intake
dc.description.keywords Food-Intake
dc.description.keywords Children
dc.description.keywords Variants
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - Health Technologies
utslib.copyright.status Open Access
utslib.copyright.date 2015-04-15 12:23:47.074767+10
pubs.consider-herdc true
utslib.collection.history School of Medical and Molecular Sciences (ID: 341)
utslib.collection.history General (ID: 2)

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