The Acute Haemodynamic Effect of Nebulised Frusemide in Stable, Advanced Heart Failure

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Show simple item record Newton, PJ Davidson, PM Krum, H Ollerton, R Macdonald, P 2012-10-12T03:34:32Z 2012-05
dc.identifier.citation Heart Lung and Circulation, 2012, 21 (5), pp. 260 - 266
dc.identifier.issn 1443-9506
dc.identifier.other C1 en_US
dc.description.abstract Purpose: To assess the acute haemodynamic effects of nebulised frusemide in a stable advanced heart failure population. Procedure: In this randomised, double blind, placebo controlled trial, people with stable, advanced heart failure undergoing right heart catheterisation were randomised to receive either 40. mg (4. ml) of nebulised frusemide or 4. ml of normal saline. Following inhalation of the study medication, subjects' pulmonary pressures were recorded every 15. min for 1. h. Findings: There were no significant changes in the weighted average time course data of the subjects (n= 32) in either group over the study period, in particular no differences were observed in haemodynamic parameters between the two groups. Weighted average pulmonary capillary wedge pressure after 60. min in the frusemide group was 22.5 (SD 6.5) mmHg (n= 14) compared to the placebo group's 24.0 (SD 7.3) mmHg (n= 18), p= 0.55. The frusemide group had a significantly greater change in the median volume of urine in the bladder over the study period (186. ml IQR 137.8-260.8) compared to the placebo group (76. ml IQR 39.0-148.0) p= 0.02. Conclusion: This study showed that nebulised frusemide had no significant clinical effect on the haemodynamic characteristics of the subjects. © 2012 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ).
dc.language eng
dc.relation.isbasedon 10.1016/j.hlc.2012.03.002
dc.title The Acute Haemodynamic Effect of Nebulised Frusemide in Stable, Advanced Heart Failure
dc.type Journal Article
dc.parent Heart Lung and Circulation
dc.journal.volume 5
dc.journal.volume 21
dc.journal.number 5 en_US
dc.publocation Australia en_US
dc.identifier.startpage 260 en_US
dc.identifier.endpage 266 en_US FOH.Faculty of Health en_US
dc.conference Verified OK en_US
dc.for 1102 Cardiorespiratory Medicine and Haematology
dc.for 1117 Public Health and Health Services
dc.personcode 111808
dc.personcode 110950
dc.personcode 117187
dc.percentage 50 en_US Cardiovascular Medicine and Haematology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US en_US
dc.location.activity en_US
dc.description.keywords Frusemide
dc.description.keywords Haemodynamics
dc.description.keywords Heart failure
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Health
pubs.organisational-group /University of Technology Sydney/Strength - Health Services and Practice Research
utslib.copyright.status Closed Access 2015-04-15 12:17:09.805752+10
pubs.consider-herdc true
utslib.collection.history Uncategorised (ID: 363)
utslib.collection.history Closed (ID: 3)

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