Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis

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dc.contributor.author Cretney, E
dc.contributor.author Takeda, K
dc.contributor.author Wiltrout, RH
dc.contributor.author Sedger, LM
dc.contributor.author Kayagaki, N
dc.contributor.author Yagita, H
dc.contributor.author Okumura, K
dc.date.accessioned 2012-10-12T03:34:32Z
dc.date.issued 2001-01
dc.identifier.citation Journal Of Experimental Medicine, 2001, 193 (6), pp. 661 - 670
dc.identifier.issn 0022-1007
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/18702
dc.description.abstract Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is expressed by in vitro activated natural killer (NK) cells, but the relevance of this observation to the biological function of NK cells has been unclear. Herein, we have demonstrated the in vivo induction of mouse TRAIL expression on various tissue NK cells and correlated NK cell activation with TRAIL-mediated antimetastatic function in vivo. Expression of TRAIL was only constitutive on a subset of liver NK cells, and innate NK cell control of Renca carcinoma hepatic metastases in the liver was partially TRAIL dependent. Administration of therapeutic doses of interleukin (IL)-12, a powerful inducer of interferon (IFN)-gamma production by NK cells and NKT cells, upregulated TRAIL expression on liver, spleen, and lung NK cells, and IL-12 suppressed metastases in both liver and lung in a TRAIL-dependent fashion. By contrast, alpha -galactosylceramide (alpha -GalCer), a powerful inducer of NKT cell IFN-gamma and IL-4 secretion, suppressed both liver and lung metastases but only stimulated NK cell TRAIL-mediated function in the liver. TRAIL. expression was not detected on NK cells from IFN-gamma -deficient mice and TRAIL-mediated antimetastatic effects of IL-12 and a-GalCer were strictly IFN-gamma dependent. These results indicated that TRAIL induction on NK cells plays a critical role in IFN-gamma -mediated antimetastatic effects of IL-12 and alpha -GalCer.
dc.format Scott McWhirter
dc.publisher Rockefeller University Press
dc.relation.isbasedon 10.1084/jem.193.6.661
dc.title Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis
dc.type Journal Article
dc.parent Journal Of Experimental Medicine
dc.journal.volume 6
dc.journal.volume 193
dc.journal.number 6 en_US
dc.publocation USA en_US
dc.identifier.startpage 661 en_US
dc.identifier.endpage 670 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 11 Medical and Health Sciences
dc.personcode 102397
dc.percentage 100 en_US
dc.classification.name Medical And Health Sciences en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords HUMAN T-CELLS; NKT CELLS; ALPHA-GALACTOSYLCERAMIDE; IN-VIVO; MEDIATED CYTOTOXICITY; RECEPTOR EXPRESSION; DENDRITIC CELLS; CUTTING EDGE; TUMORICIDAL ACTIVITY; IMMUNE-RESPONSES en_US
dc.description.keywords HUMAN T-CELLS
dc.description.keywords NKT CELLS
dc.description.keywords ALPHA-GALACTOSYLCERAMIDE
dc.description.keywords IN-VIVO
dc.description.keywords MEDIATED CYTOTOXICITY
dc.description.keywords RECEPTOR EXPRESSION
dc.description.keywords DENDRITIC CELLS
dc.description.keywords CUTTING EDGE
dc.description.keywords TUMORICIDAL ACTIVITY
dc.description.keywords IMMUNE-RESPONSES
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
utslib.collection.history Closed (ID: 3)
utslib.collection.history Uncategorised (ID: 363)


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