Oxidation of MDMA in urine after exposure to bleach

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dc.contributor.author Pham, AQ
dc.contributor.author Fu, S
dc.contributor.author Dawson, M
dc.contributor.editor Gerostamoulos, D
dc.contributor.editor Beyer, J
dc.date.accessioned 2012-10-12T03:35:55Z
dc.date.issued 2011-01
dc.identifier.citation TIAFT Bulletin, 2011, 41 pp. 49 - 51
dc.identifier.other E1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/19066
dc.description.abstract For the drug testing of MDMA (3,4-methylenedioxymethamphetamine or 'ecstasy') and other drugs of abuse, urine is generally the matrix of choice. However, the main issue concerned with urine drug testing is the lack of sample integrity due to acts of urine adulteration. A novel approach in the fight against urine adulteration is researched in this article, involving the use of LC-MS/MS (liquid chromatography-tandem mass spectrometry) to study and identify stable reaction products between the chemical reaction of MDMA and hypochlorite. Samples were analysed on an X Bridge C 18 column ( 150mm x 4.6mm, 3.51-Jm, Waters). Chromatographic separation was achieved at a tlow rate of 0.3ml/min using gradient elution involving 2mM ammonium formate solution in Milli-Q water and acetonitrile as the mobile phases. Kinetic experiments were performed whereby 11-JL of urinary reaction mixture was injected every 30min of reaction. One major reaction product, N-chloroMDMA, was formed and found to be unstable at room temperature (20°C), possibly reverting back into MDMA. It is suggested that bleach may possibly be able to oxidise a low dosage of MDMA to below cutoff concentration values and thus, conceal MDMA use. However, more research is required.
dc.format Jessica Robinson
dc.publisher GI Printing & Graphics
dc.title Oxidation of MDMA in urine after exposure to bleach
dc.type Conference Proceeding
dc.parent TIAFT Bulletin
dc.journal.volume 41
dc.journal.number en_US
dc.publocation Australia en_US
dc.publocation Australia
dc.identifier.startpage 49 en_US
dc.identifier.endpage 51 en_US
dc.cauo.name SCI.Chemistry and Forensic Sciences en_US
dc.conference Verified OK en_US
dc.conference The international Association of Forensic Toxicologist (TIAFT) 2010 Meeting
dc.conference The international Association of Forensic Toxicologist (TIAFT) 2010 Meeting
dc.for 030499 Medicinal and Biomolecular Chemistry Not Elsewhere Classified
dc.personcode 910324
dc.personcode 103806
dc.percentage 100 en_US
dc.classification.name Medicinal and Biomolecular Chemistry not elsewhere classified en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom The international Association of Forensic Toxicologist (TIAFT) 2010 Meeting en_US
dc.date.activity 20100829 en_US
dc.date.activity 2010-08-29
dc.date.activity 2010-08-29
dc.location.activity Bonn, Germany en_US
dc.location.activity Bonn, Germany
dc.description.keywords mdma, ecstacy, drug masking, masking agents, urine testing
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Faculty of Science/School of Chemistry and Forensic Science
pubs.organisational-group /University of Technology Sydney/Strength - Forensic Science
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
pubs.consider-herdc false
utslib.collection.history Closed (ID: 3)

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