Synthesis and impurity profiling of MDMA prepared from commonly available starting materials

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dc.contributor.author Gallagher, R
dc.contributor.author Shimmon, R
dc.contributor.author McDonagh, AM
dc.date.accessioned 2014-04-03T01:22:27Z
dc.date.issued 2012-11-30
dc.identifier.citation Forensic Science International, 2012, 223 (1-3), pp. 306 - 313
dc.identifier.issn 0379-0738
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/22786
dc.description.abstract This work examines the synthesis of 3,4-methylenedioxy-N-methylamphetamine (MDMA) from common starting materials that may be utilised by clandestine laboratory operators. Piperonal was prepared from two common starting materials, piperine (from pepper) and vanillin (a common flavouring). Piperine was converted to piperonal by ozonolysis and oxidative cleavage with potassium permanganate and tetrahydrofuran. Vanillin was converted to piperonal by demethylation with pyridine and aluminium chloride followed by methylenation with dichloromethane. The resulting piperonal samples were converted via a commonly encountered route to MDMA. The impurities that indicate a particular route were identified and the feasibility of each method was also assessed. © 2012 Elsevier Ireland Ltd.
dc.language eng
dc.relation.isbasedon 10.1016/j.forsciint.2012.10.006
dc.subject Chemical synthesis, Ecstasy, Illicit drugs, Impurity profiling, MDMA, REDUCTIVE AMINATION, 3,4-METHYLENEDIOXYMETHAMPHETAMINE, SAMPLES, Legal & Forensic Medicine
dc.subject Chemical synthesis; Ecstasy; Illicit drugs; Impurity profiling; MDMA; REDUCTIVE AMINATION; 3,4-METHYLENEDIOXYMETHAMPHETAMINE; SAMPLES; Legal & Forensic Medicine
dc.title Synthesis and impurity profiling of MDMA prepared from commonly available starting materials
dc.type Journal Article
dc.parent Forensic Science International
dc.journal.volume 1-3
dc.journal.volume 223
dc.journal.number 1-3 en_US
dc.publocation Clare en_US
dc.identifier.startpage 306 en_US
dc.identifier.endpage 313 en_US
dc.cauo.name FOH.Faculty of Health en_US
dc.conference Verified OK en_US
dc.for 0399 Other Chemical Sciences
dc.personcode 111978 en_US
dc.personcode 980366 en_US
dc.personcode 030871 en_US
dc.percentage 100 en_US
dc.classification.name Other Chemical Sciences en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords REDUCTIVE AMINATION; 3,4-METHYLENEDIOXYMETHAMPHETAMINE; SAMPLES en_US
dc.description.keywords Chemical synthesis
dc.description.keywords Ecstasy
dc.description.keywords Illicit drugs
dc.description.keywords Impurity profiling
dc.description.keywords MDMA
dc.staffid 030871 en_US
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Faculty of Science/School of Chemistry and Forensic Science
pubs.organisational-group /University of Technology Sydney/Strength - Forensic Science
pubs.organisational-group /University of Technology Sydney/Strength - Materials and Technology for Energy Efficiency


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