Characterization of P-gp Expression and Function vs. Time and Passage in the Calu-3 Air-Interface Model for Drug Delivery to the Lung

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Show simple item record Haghi, M Young, P Traini, D Bebawy, M
dc.contributor.editor Dalby, RN
dc.contributor.editor Byron, PR
dc.contributor.editor Peart, J
dc.contributor.editor Suman, JD
dc.contributor.editor Farr, SJ
dc.contributor.editor Young, PM 2014-04-03T01:24:29Z 2010-01
dc.identifier.citation Proceedings of Respiratory Drug Delivery 2010, 2010, 3 pp. 875 - 878
dc.identifier.isbn 1-933722-41-X
dc.identifier.other E1UNSUBMIT en_US
dc.description.abstract Calu-3, a sub-bronchial epithelial cell line, cultured at the air-interfaced, has been shown to be a very reliable model for the in vitro investigation of inhalation drug delivery to the upper airways. It has been found to be superior with respect to morphology and function when compared to the liquid covered culture model (1, 2), but the Calu-3 air-interface model has not been fully investigated for P-glycoprotein (P-gp) expression (3, 4) a parameter that could influence predicted drug delivery in the lung. P-gp is a plasma membrane drug transporter, actively involved in `carrying a wide range of structurally and functionally unrelated drugs out of cells (5). P-gp has been shown to interact with some drugs routinely used in respiratory therapy (1). Another factor that may affect drug transport across the epithelium is the presence of mucus; which, in healthy lungs, aids mucociliary clearance of deposited particulate matter, acts as an antibacterial substance and prevents loss of excessive fluid from the airway due to evaporation (6). The aim of this investigation was to characterize mucus secretion and cell surface P-gp expression and function in the Calu-3 air-interface model.
dc.format Scott McWhirter
dc.publisher Davis Healthcare Int'
dc.title Characterization of P-gp Expression and Function vs. Time and Passage in the Calu-3 Air-Interface Model for Drug Delivery to the Lung
dc.type Conference Proceeding
dc.parent Proceedings of Respiratory Drug Delivery 2010
dc.journal.volume 3
dc.journal.number en_US
dc.publocation Illnois USA en_US
dc.publocation Illnois USA
dc.identifier.startpage 875 en_US
dc.identifier.endpage 878 en_US GSH.Pharmacy en_US
dc.conference Verified OK en_US
dc.conference Respiratory Drug Delivery 2010
dc.conference Respiratory Drug Delivery 2010
dc.for 1115 Pharmacology and Pharmaceutical Sciences
dc.personcode 112474
dc.personcode 121355
dc.personcode 121357
dc.personcode 122588
dc.percentage 100 en_US Pharmacology and Pharmaceutical Sciences en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom Respiratory Drug Delivery 2010 en_US 20100425 en_US 2010-04-25 2010-04-25
dc.location.activity Orlando, Florida en_US
dc.location.activity Orlando, Florida
dc.description.keywords respiratory epithelium, Calu-3, P-glycoprotein (P-gp), permeability, efflux
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Graduate School of Health
pubs.organisational-group /University of Technology Sydney/Strength - Health Technologies
utslib.copyright.status Closed Access 2015-04-15 12:17:09.805752+10
pubs.consider-herdc false
utslib.collection.history Closed (ID: 3)
utslib.collection.history Uncategorised (ID: 363)

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