Fasciola hepatica: The therapeutic potential of a worm secretome

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dc.contributor.author Robinson, MW
dc.contributor.author Dalton, JP
dc.contributor.author O'Brien, BA
dc.contributor.author Donnelly, S
dc.date.accessioned 2014-04-03T01:53:21Z
dc.date.issued 2013-03
dc.identifier.citation International Journal for Parasitology, 2013, 43 (3-4), pp. 283 - 291
dc.identifier.issn 0020-7519
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/23431
dc.description.abstract The success of helminth parasites is partly related to their ability to modulate host immune responses towards an anti-inflammatory/regulatory phenotype. This ability resides with the molecules contained in the secretome of various helminths that have been shown to interact with host immune cells and influence their function. Consequently, there exists a unique opportunity to exploit these molecules for the prophylactic and therapeutic treatment of human pro- and auto-inflammatory disorders (for example septic shock, transplant rejection and autoimmune disease). In this review, we describe the mechanisms used by the trematode parasite, Fasciola hepatica, to modulate the immune responses of its host and discuss the potent immune-modulatory effects of three individual molecules within the secretome; namely cathepsin L1, peroxiredoxin and helminth defence molecule. With a focus on the requirements from industry, we discuss the strategies by which these molecules may be clinically developed to control human immune responses in a way that is conducive to the prevention of immune-mediated diseases. © 2012.
dc.language eng
dc.relation.isbasedon 10.1016/j.ijpara.2012.11.004
dc.title Fasciola hepatica: The therapeutic potential of a worm secretome
dc.type Journal Article
dc.parent International Journal for Parasitology
dc.journal.volume 3-4
dc.journal.volume 43
dc.journal.number 3-4 en_US
dc.publocation Oxford, UK en_US
dc.identifier.startpage 283 en_US
dc.identifier.endpage 291 en_US
dc.cauo.name SCI.School of Medical and Molecular Sciences en_US
dc.conference Verified OK en_US
dc.for 0707 Veterinary Sciences
dc.personcode 030027
dc.personcode 995261
dc.personcode 030896
dc.personcode 100777
dc.percentage 100 en_US
dc.classification.name Veterinary Sciences en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords Cysteine protease
dc.description.keywords Diabetes
dc.description.keywords Fasciola hepatica
dc.description.keywords Helminth defence molecule
dc.description.keywords Macrophage
dc.description.keywords Peroxiredoxin
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - Health Technologies
pubs.organisational-group /University of Technology Sydney/Strength - i3
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
pubs.consider-herdc true
utslib.collection.history School of Medical and Molecular Sciences (ID: 341)
utslib.collection.history School of Medical and Molecular Sciences (ID: 341)
utslib.collection.history Closed (ID: 3)


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