Synergism between medihoney and rifampicin against methicillin-resistant Staphylococcus aureus (MRSA)

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Show simple item record Carter, Dee en_US Schlothauer, Ralf en_US Alber, Dagmar en_US Turnbull, Lynne en_US Whitchurch, Cynthia en_US Muller, Patrick en_US Harry, Elizabeth en_US
dc.contributor.editor en_US 2013-11-03T17:05:39Z 2013-11-03T17:05:39Z 2013 en_US
dc.identifier 2012001847 en_US
dc.identifier.citation Carter, Dee et al. 2013, 'Synergism between medihoney and rifampicin against methicillin-resistant Staphylococcus aureus (MRSA)', Public library of Science, vol. 8, no. 2, pp. e57679 en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.other C1 en_US
dc.description.abstract Skin and chronic wound infections caused by highly antibiotic resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) are an increasing and urgent health problem worldwide, particularly with sharp increases in obesity and diabetes. New Zealand manuka honey has potent broad-spectrum antimicrobial activity, has been shown to inhibit the growth of MRSA strains, and bacteria resistant to this honey have not been obtainable in the laboratory. Combinational treatment of chronic wounds with manuka honey and common antibiotics may offer a wide range of advantages including synergistic enhancement of the antibacterial activity, reduction of the effective dose of the antibiotic, and reduction of the risk of antibiotic resistance. The aim of this study was to investigate the effect of Medihoney in combination with the widely used antibiotic rifampicin on S. aureus. Using checkerboard microdilution assays, time-kill curve experiments and agar diffusion assays, we show a synergism between Medihoney and rifampicin against MRSA and clinical isolates of S. aureus. Furthermore, the Medihoney/rifampicin combination stopped the appearance of rifampicin-resistant S. aureus in vitro. Methylglyoxal (MGO), believed to be the major antibacterial compound in manuka honey, did not act synergistically with rifampicin and is therefore not the sole factor responsible for the synergistic effect of manuka honey with rifampicin. Our findings support the idea that a combination of honey and antibiotics may be an effective new antimicrobial therapy for chronic wound infections. en_US
dc.language en_US
dc.publisher Public library of Science en_US
dc.relation.isbasedon en_US
dc.title Synergism between medihoney and rifampicin against methicillin-resistant Staphylococcus aureus (MRSA) en_US
dc.parent PLoS One en_US
dc.journal.volume 8 en_US
dc.journal.number 2 en_US
dc.publocation USA en_US
dc.identifier.startpage e57679 en_US
dc.identifier.endpage en_US SCI.Institute for Biotechnology of Infectious Diseases en_US
dc.conference Verified OK en_US
dc.for 110800 en_US
dc.personcode 0000091937 en_US
dc.personcode 0000091943 en_US
dc.personcode 0000091944 en_US
dc.personcode 103744 en_US
dc.personcode 103745 en_US
dc.personcode 111364 en_US
dc.personcode 995003 en_US
dc.percentage 100 en_US Medical Microbiology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US en_US
dc.location.activity en_US
dc.staffid 995003 en_US
utslib.copyright.status Closed Access 2015-04-15 12:17:09.805752+10

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