A rapid CZE method for the analysis of benzodiazepines in spiked beverages.

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dc.contributor.author Webb, R
dc.contributor.author Doble, P
dc.contributor.author Dawson, M
dc.date.accessioned 2009-11-12T04:41:10Z
dc.date.issued 2007-10
dc.identifier.citation Electrophoresis, 2007, 28 (19), pp. 3553 - 3565
dc.identifier.issn 0173-0835
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/3217
dc.description.abstract A rapid CZE method was developed for the simultaneous determination of nine benzodiazepines in spiked beverages (nitrazepam oxazepam, alprazolam, flunitrazepam, temazepam, diazepam, 7-aminoflunitrazepam, 7-aminonitrazepam and 7-aminoclonazepam). The method employed a double-coated capillary coated with poly(diallyldimethylammonium chloride) and then dextran sulphate. The BGE conditions were 100 mM ammonium phosphate buffer, pH 2.5, which gave baseline resolution between consecutive peaks and a run time of less than 6.5 min. This method offers improvements in both resolution and run time, compared to those attained under analogous conditions with an uncoated capillary. The validated method was successfully applied to beverages that had been spiked with benzodiazepines at concentrations simulating prescription tablets. No sample pretreatment was required to quantify five benzodiazepines in Coca-Cola, orange juice, beer, bourbon and Bacardi. The exception was white wine, where the complex sample matrix did not enable the accurate quantification of nitrazepam.
dc.format Print
dc.language eng
dc.relation.isbasedon 10.1002/elps.200700110
dc.title A rapid CZE method for the analysis of benzodiazepines in spiked beverages.
dc.type Journal Article
dc.parent Electrophoresis
dc.journal.volume 19
dc.journal.volume 28
dc.journal.number 19 en_US
dc.publocation Weinheim en_US
dc.identifier.startpage 3553 en_US
dc.identifier.endpage 3565 en_US
dc.cauo.name SCI.Chemistry and Forensic Sciences en_US
dc.conference Verified OK en_US
dc.for 0399 Other Chemical Sciences
dc.personcode 910324
dc.personcode 010494
dc.percentage 100 en_US
dc.classification.name Other Chemical Sciences en_US
dc.classification.type FOR-08 en_US
dc.location.activity ISI:000250294200022 en_US
dc.description.keywords Phosphates
dc.description.keywords Benzodiazepines
dc.description.keywords Dextran Sulfate
dc.description.keywords Calibration
dc.description.keywords Electrophoresis, Capillary
dc.description.keywords Coated Materials, Biocompatible
dc.description.keywords Sensitivity and Specificity
dc.description.keywords Reproducibility of Results
dc.description.keywords Spectrophotometry, Ultraviolet
dc.description.keywords Alcoholic Beverages
dc.description.keywords Beverages
dc.description.keywords Polyethylenes
dc.description.keywords Hydrogen-Ion Concentration
dc.description.keywords Forensic Toxicology
dc.description.keywords Quaternary Ammonium Compounds
dc.description.keywords Anti-Anxiety Agents
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Faculty of Science/School of Chemistry and Forensic Science
pubs.organisational-group /University of Technology Sydney/Strength - Forensic Science
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
pubs.consider-herdc true
utslib.collection.history Closed (ID: 3)

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