Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro

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Show simple item record Rashid, I van Reyk, DM Davies, MJ 2009-12-21T02:30:10Z 2007-03-06
dc.identifier.citation FEBS Letters, 2007, 581 (5), pp. 1067 - 1070
dc.identifier.issn 0014-5793
dc.identifier.other C1 en_US
dc.description.abstract Glycation of low-density lipoprotein (LDL) by reactive aldehydes, such as glycolaldehyde, can result in the cellular accumulation of cholesterol in macrophages. In this study, it is shown that carnosine, or its constituent amino acids β-alanine and l-histidine, can inhibit the modification of LDL by glycolaldehyde when present at equimolar concentrations to the modifying agent. This protective effect was accompanied by inhibition of cholesterol and cholesteryl ester accumulation in human monocyte-derived macrophages incubated with the glycated LDL. Thus, carnosine and its constituent amino acids may have therapeutic potential in preventing diabetes-induced atherosclerosis. © 2007 Federation of European Biochemical Societies.
dc.language eng
dc.relation.isbasedon 10.1016/j.febslet.2007.01.082
dc.title Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro
dc.type Journal Article
dc.parent FEBS Letters
dc.journal.volume 5
dc.journal.volume 581
dc.journal.number 5 en_US
dc.publocation Netherlands en_US
dc.identifier.startpage 1067 en_US
dc.identifier.endpage 1070 en_US SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 0601 Biochemistry and Cell Biology
dc.personcode 000788
dc.percentage 100 en_US Biochemistry and Cell Biology en_US
dc.classification.type FOR-08 en_US
dc.description.keywords Aldehyde
dc.description.keywords Atherosclerosis
dc.description.keywords Carnosine
dc.description.keywords Foam cell
dc.description.keywords Glycation
dc.description.keywords Low-density lipoprotein
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
utslib.copyright.status Closed Access 2015-04-15 12:17:09.805752+10
pubs.consider-herdc true
utslib.collection.history School of Medical and Molecular Sciences (ID: 341)
utslib.collection.history Closed (ID: 3)

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