Expression of putative virulence factors of Escherichia coli O157:H7 differs in bovine and human infections

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dc.contributor.author Rashid, RA
dc.contributor.author Tabata, TA
dc.contributor.author Oatley, MJ
dc.contributor.author Besser, TE
dc.contributor.author Tarr, P
dc.contributor.author Moseley, S
dc.date.accessioned 2009-12-21T02:30:18Z
dc.date.issued 2006-01
dc.identifier.citation Infection And Immunity, 2006, 74 (7), pp. 4142 - 4148
dc.identifier.issn 0019-9567
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/3826
dc.description.abstract Escherichia coli O157:H7 is a commensal organism in cattle, but it is a pathogen in humans. This differential expression of virulence suggests that specific virulence factors are regulated differently in human and bovine hosts. To test this hypothesis, relative real-time reverse transcription-PCR was used to relate the expression of several putative virulence genes (eae, espA, stx2, rfbE, ehxA, and iha) to that of the "housekeeping" gene gnd during natural human and experimental bovine infection with E. coli O157:H7. We examined these genes in fecal samples from eight humans and four calves. iha and espA were significantly more expressed in bovine infections. rfbE and ehxA appeared to be more highly expressed in human infections, though these differences did not achieve statistical significance. Our results support the hypothesis that some virulence-associated genes of O157:H7 are differentially expressed in a host-specific manner.
dc.publisher Amer Soc Microbiology
dc.relation.isbasedon 10.1128/IAI.00299-06
dc.title Expression of putative virulence factors of Escherichia coli O157:H7 differs in bovine and human infections
dc.type Journal Article
dc.parent Infection And Immunity
dc.journal.volume 7
dc.journal.volume 74
dc.journal.number 7 en_US
dc.publocation Washington DC, USA en_US
dc.identifier.startpage 4142 en_US
dc.identifier.endpage 4148 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 0605 Microbiology
dc.personcode 100098
dc.percentage 100 en_US
dc.classification.name Microbiology en_US
dc.classification.type FOR-08 en_US
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science


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