A new assembly pathway for the cytokinetic Z ring from a dynamic helical structure in vegetatively growing cells of Bacillus subtilis

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dc.contributor.author Peters, PC
dc.contributor.author Migocki, M
dc.contributor.author Thoni, C
dc.contributor.author Harry, L
dc.date.accessioned 2009-12-21T02:30:18Z
dc.date.issued 2007-01
dc.identifier.citation Molecular Microbiology, 2007, 64 (2), pp. 487 - 499
dc.identifier.issn 0950-382X
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/3829
dc.description.abstract The earliest event in bacterial cell division is the formation of a Z ring, composed of the tubulin-like FtsZ protein, at the division site at midcell. This ring then recruits several other division proteins and together they drive the formation of a division of septum between two replicated chromosomes. Here we show that, in addition to forming a cytokinetic ring, FtsZ localises in a helical-like pattern in vegetatively growing cells of Bacillus subtilis. FtsZ moves rapudly within this helix-like structure. Examination of FtsZ localisation in individual live cells undergoing a single cell cycle suggests a new assembly mechanism for Z ring formation tha involves a cell cycle-mediated multistep remodelling of FtsZ polymers. Our observations suggest that initially FtsZ localises in a helical pattern, with movement of FtsZ within this sturcture occurring along the entire length of the cell. Next, movement of FtsZ in a helical-like pattern is restricted to a central region of the cell. Finally the FtsZ ring forms precisely at midcell. We further show that another division protein, FtsA, shown to interact with FtsZ prior to Z ring formation in B. subtilis, also localises to similar helical patterns in vegetatively growing cells.
dc.publisher Blackwell Publishing
dc.relation.isbasedon 10.1111/j.1365-2958.2007.05673.x
dc.title A new assembly pathway for the cytokinetic Z ring from a dynamic helical structure in vegetatively growing cells of Bacillus subtilis
dc.type Journal Article
dc.parent Molecular Microbiology
dc.journal.volume 2
dc.journal.volume 64
dc.journal.number 2 en_US
dc.publocation Oxford, England en_US
dc.identifier.startpage 487 en_US
dc.identifier.endpage 499 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 0605 Microbiology
dc.personcode 996413
dc.personcode 995003
dc.percentage 100 en_US
dc.classification.name Microbiology en_US
dc.classification.type FOR-08 en_US
dc.description.keywords N/A en_US
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - i3
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
utslib.collection.history Closed (ID: 3)

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