The cell-mediated immune response to Neospora caninum during pregnancy in the mouse is associated with a bias towards production of interleukin-4

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Show simple item record Quinn, HE Miller, CMD Ellis, JT 2009-12-21T02:30:45Z 2004-05
dc.identifier.citation International Journal for Parasitology, 2004, 34 (6), pp. 723 - 732
dc.identifier.issn 0020-7519
dc.identifier.other C1 en_US
dc.description.abstract Neospora caninum is an obligate intracellular protozoan parasite which is efficiently transmitted transplacentally in cattle where it may cause abortion. A pregnant mouse model was used to characterise the immune response following N. caninum infection; the response in non-pregnant and pregnant mice was compared. Spleen cells from both infected/non-pregnant and infected/pregnant mice produced interferon-γ, interleukin-12 and tumour necrosis factor α; however, the levels of these Th1 cytokines were lower in infected/pregnant mice. Infected/non-pregnant and infected/pregnant mice also produced the Th2 cytokine interleukin-10; however, there was no trend toward a decrease of this in pregnant mice. Interleukin-4 was exclusively produced at high levels by infected/pregnant mice and thus appears responsible for the observed decline in Th1 cytokine production in pregnant mice. A bias towards Th2 cytokines such as IL-4 and IL-10 is normally associated with the maintenance of a viable pregnancy, and not with the control of protozoal infections. Consequently, the importance and role of cytokines and cell-mediated immunity in the control of transplacental transmission and foetal loss due to N. caninum infection are discussed. © 2004 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
dc.language eng
dc.relation.isbasedon 10.1016/j.ijpara.2004.01.007
dc.title The cell-mediated immune response to Neospora caninum during pregnancy in the mouse is associated with a bias towards production of interleukin-4
dc.type Journal Article
dc.description.version Published
dc.parent International Journal for Parasitology
dc.journal.volume 6
dc.journal.volume 34
dc.publocation Oxford en_US
dc.identifier.startpage 723 en_US
dc.identifier.endpage 732 en_US SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 0707 Veterinary Sciences
dc.personcode 970043
dc.personcode 910945
dc.percentage 100 en_US Veterinary Sciences en_US
dc.classification.type FOR-08 en_US
dc.description.keywords Cytokine
dc.description.keywords Immunity
dc.description.keywords Neospora caninum
dc.description.keywords Pregnancy
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - i3
utslib.copyright.status Closed Access 2015-04-15 12:17:09.805752+10
pubs.consider-herdc true
utslib.collection.history Closed (ID: 3)

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