Acid-cleavable polymeric core-shell particles for delivery of hydrophobic drugs

DSpace/Manakin Repository

Search OPUS


Advanced Search

Browse

My Account

Show simple item record

dc.contributor.author Chan, Y
dc.contributor.author Bulmus, V
dc.contributor.author Zareie, HM
dc.contributor.author Byrne, F
dc.contributor.author Barner, L
dc.contributor.author Kavallaris, M
dc.date.accessioned 2009-12-21T02:32:15Z
dc.date.issued 2006-01
dc.identifier.citation Journal of Controlled Release, 2006, 115 (2), pp. 197 - 207
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/4209
dc.description.abstract Here we describe the combined use of acid-labile microgel approach and RAFT-mediated seeded despersion polymerisation technique to prepare an acid-cleavable core-shell like polymeric colloidal system for the delivery of hydrophobic drugs at slightly acidic sites. A new bisacrylate acetal crosslinker was copolymerised with n-butyl acrylate (BA) in the presence of a RAFT agent using a dispersion polymerisation technique, which yieled crosslinked spherical particles with the size ranging between 150 and 500 nm. The particles were cleaved in a pH-dependent manner similar to the acid-labile hydrolysis behaviour of the crosslinker. In order to mask the hydrophobic surface of the particles, polyethelene glycol acrylate (PEG-A) was grafted onto poly(BA) seed particles via the RAFT agent groups on the particle surface. The acidic-site selective delivery protential of the poly(BA)-g-poly(PEG-A) particles was assessed in-vitro using a lipophilic flueorescent dye as a model hydrophobic drug. Ca. 73% and 34% of the total dye loaded in the paerticles was found to be released at pH 5.0 and 7.4 in 24h, respectively. Thegrowth of human neuroblastoma cells was not affected by the incubation with the core-shell particles and their cleavage by-products upto 3 mg/ml concentration. The physiocochemical and the functional features support the potential value of the acid-cleavable poly(BA) core-poly(PEG-A) shell particles as carriers for the delivery of hydrophobic drugs at acidic sites.
dc.publisher Elsevier
dc.relation.isbasedon 10.1016/j.jconrel.2006.07.025
dc.title Acid-cleavable polymeric core-shell particles for delivery of hydrophobic drugs
dc.type Journal Article
dc.parent Journal of Controlled Release
dc.journal.volume 2
dc.journal.volume 115
dc.journal.number 2 en_US
dc.publocation Amsterdam, the Netherlands en_US
dc.identifier.startpage 197 en_US
dc.identifier.endpage 207 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 090399 Biomedical Engineering Not Elsewhere Classified
dc.personcode 030414
dc.percentage 100 en_US
dc.classification.name Biomedical Engineering not elsewhere classified en_US
dc.classification.type FOR-08 en_US
dc.description.keywords pH-sensitive particles; drug delivery; PEG grafting; despersion polymerisation; reversible addition-fragmentaion chain transfer (RAFT) en_US
dc.description.keywords Extended Information Filter (EIF)
dc.description.keywords Extended Kalman Filter (EKF)
dc.description.keywords Nonlinear Model Predictive Control
dc.description.keywords Optimization
dc.description.keywords Simultaneous localization and map building (SLAM)
dc.description.keywords Target localization
dc.description.keywords pH-sensitive particles
dc.description.keywords drug delivery
dc.description.keywords PEG grafting
dc.description.keywords despersion polymerisation
dc.description.keywords reversible addition-fragmentaion chain transfer (RAFT)
dc.description.keywords pH-sensitive particles
dc.description.keywords drug delivery
dc.description.keywords PEG grafting
dc.description.keywords despersion polymerisation
dc.description.keywords reversible addition-fragmentaion chain transfer (RAFT)
dc.description.keywords pH-sensitive particles
dc.description.keywords pH-sensitive particles
dc.description.keywords drug delivery
dc.description.keywords drug delivery
dc.description.keywords PEG grafting
dc.description.keywords PEG grafting
dc.description.keywords despersion polymerisation
dc.description.keywords despersion polymerisation
dc.description.keywords reversible addition-fragmentaion chain transfer (RAFT)
dc.description.keywords reversible addition-fragmentaion chain transfer (RAFT)
dc.description.keywords pH-sensitive particles
dc.description.keywords drug delivery
dc.description.keywords PEG grafting
dc.description.keywords despersion polymerisation
dc.description.keywords reversible addition-fragmentaion chain transfer (RAFT)
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Faculty of Science/School of Physics and Advanced Materials
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10


Files in this item

This item appears in the following Collection(s)

Show simple item record