Targeted destruction of murine macrophage cells with bioconjugated gold nanorods

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Show simple item record Pissuwan, D Valenzuela, SM Killingsworth, MC Xu, X Cortie, MB 2009-12-21T02:33:00Z 2007-12
dc.identifier.citation Journal of Nanoparticle Research, 2007, 9 (6), pp. 1109 - 1124
dc.identifier.issn 1388-0764
dc.identifier.other C1 en_US
dc.description.abstract Gold nanorods manifest a readily tunable longitudinal plasmon resonance with light and consequently have potential for use in photothermal therapeutics. Recent work by others has shown how gold nanoshells and rods can be used to target cancer cells, which can then be destroyed using relatively high power laser radiation (∼1×105 to 1×1010 W/m 2). Here we extend this concept to demonstrate how gold nanorods can be modified to bind to target macrophage cells, and show that high intensity laser radiation is not necessary, with even 5×102 W/m 2 being sufficient, provided that a total fluence of ∼30 J/cm2 is delivered. We used the murine cell line RAW 264.7 and the monoclonal antibody CD11b, raised against murine macrophages, as our model system and a 5 mW solid state diode laser as our energy source. Exposure of the cells labeled with gold nanorods to a laser fluence of 30 J/cm2 resulted in 81% cell death compared to only 0.9% in the control, non-labeled cells. © 2007 Springer Science+Business Media, Inc.
dc.language eng
dc.relation.isbasedon 10.1007/s11051-007-9212-z
dc.title Targeted destruction of murine macrophage cells with bioconjugated gold nanorods
dc.type Journal Article
dc.parent Journal of Nanoparticle Research
dc.journal.volume 6
dc.journal.volume 9
dc.journal.number en_US
dc.journal.number 6 en_US
dc.publocation Dordrecht, Netherlands en_US
dc.identifier.startpage 1109 en_US
dc.identifier.endpage 1124 en_US SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics
dc.for 0912 Materials Engineering
dc.personcode 020302
dc.personcode 030958
dc.personcode 010690
dc.personcode 102551
dc.percentage 50 en_US Materials Engineering en_US
dc.classification.type FOR-08 en_US
dc.description.keywords Active and passive targeting
dc.description.keywords Biomedicine
dc.description.keywords Hyperthermal therapy
dc.description.keywords Nanobiotechnology
dc.description.keywords Plasmon resonance
dc.description.keywords Plasmonic heating
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - Health Technologies
utslib.copyright.status Closed Access 2015-04-15 12:17:09.805752+10
pubs.consider-herdc true
utslib.collection.history Closed (ID: 3)
utslib.collection.history School of Medical and Molecular Sciences (ID: 341)

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