Arachnid toxinology in Australia: From clinical toxicology to potential applications

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dc.contributor.author Nicholson, GM
dc.contributor.author Graudins, A
dc.contributor.author Wilson, HI
dc.contributor.author Little, M
dc.contributor.author Broady, KW
dc.date.accessioned 2009-12-21T02:34:15Z
dc.date.issued 2006-12-01
dc.identifier.citation Toxicon, 2006, 48 (7), pp. 872 - 898
dc.identifier.issn 0041-0101
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/4648
dc.description.abstract The unique geographic isolation of Australia has resulted in the evolution of a distinctive range of Australian arachnid fauna. Through the pioneering work of a number of Australian arachnologists, toxinologists, and clinicians, the taxonomy and distribution of new species, the effective clinical treatment of envenomation, and the isolation and characterisation of the many distinctive neurotoxins, has been achieved. In particular, work has focussed on several Australian arachnids, including red-back and funnel-web spiders, paralysis ticks, and buthid scorpions that contain neurotoxins capable of causing death or serious systemic envenomation. In the case of spiders, species-specific antivenoms have been developed to treat envenomed patients that show considerable cross-reactivity. Both in vitro and clinical case studies have shown they are particularly efficacious in the treatment of envenomation by spiders even from unrelated families. Despite their notorious reputation, the high selectivity and potency of a unique range of toxins from the venom of Australian arachnids will make them invaluable molecular tools for studies of neurotransmitter release and vesicle exocytosis as well as ion channel structure and function. The venoms of funnel-web spiders, and more recently Australian scorpions, have also provided a previously untapped rich source of insect-selective neurotoxins for the future development of biopesticides and the characterisation of previously unvalidated insecticide targets. This review provides a historical viewpoint of the work of many toxinologists to isolate and characterise just some of the toxins produced by such a unique group of arachnids and examines the potential applications of these novel peptides. © 2006 Elsevier Ltd. All rights reserved.
dc.language eng
dc.relation.hasversion Accepted Manuscript version en_US
dc.relation.isbasedon 10.1016/j.toxicon.2006.07.025
dc.title Arachnid toxinology in Australia: From clinical toxicology to potential applications
dc.type Journal Article
dc.description.version Published
dc.parent Toxicon
dc.journal.volume 7
dc.journal.volume 48
dc.journal.number 7 en_US
dc.publocation Amsterdam, The Netherlands en_US
dc.identifier.startpage 872 en_US
dc.identifier.endpage 898 en_US
dc.cauo.name FEIT. A/DRsch Ctre for Health Technologies en_US
dc.conference Verified OK en_US
dc.for 111506 Toxicology (Incl. Clinical Toxicology)
dc.personcode 004814
dc.personcode 970435
dc.personcode 920537
dc.personcode 870145
dc.personcode 850065
dc.percentage 100 en_US
dc.classification.name Toxicology (incl. Clinical Toxicology) en_US
dc.classification.type FOR-08 en_US
dc.custom 2.3 en_US
dc.description.keywords α-Latrotoxin
dc.description.keywords Antivenom
dc.description.keywords Atracotoxins
dc.description.keywords Australian paralysis tick
dc.description.keywords Australian scorpions
dc.description.keywords Australian spiders
dc.description.keywords Bioinsecticide
dc.description.keywords Missulenatoxins
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - Health Technologies
utslib.copyright.status Open Access
utslib.copyright.date 2015-04-15 12:23:47.074767+10
pubs.consider-herdc true
utslib.collection.history General (ID: 2)
utslib.collection.history School of Medical and Molecular Sciences (ID: 341)


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