The Contribution Of Apolipoprotein E Alleles On Cognitive Performance And Dynamic Neural Activity Over Six Decades

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Show simple item record Alexander, David en_US Williams, Lea en_US Gatt, Jm en_US Dobson-Stone, C en_US Kuan, Sa en_US Todd, Eg en_US Schofield, Penelope en_US Cooper, Nicholas en_US 2009-12-21T02:39:06Z 2009-12-21T02:39:06Z 2007 en_US
dc.identifier 2006015382 en_US
dc.identifier.citation Alexander, D. et al. 2001 'The Contribution Of Apolipoprotein E Alleles On Cognitive Performance And Dynamic Neural Activity Over Six Decades', Biological Psychology, vol. 75, no. 3, pp. 2243-2251. en_US
dc.identifier.issn 0301-0511 en_US
dc.identifier.other C1 en_US
dc.description.abstract Neuroimaging shows brain-functional differences due to apolipoprotein E (APOE) polymorphisms may exist decades before the increased risk period for Alzheimer's disease, but little is known about their effect on cognition and brain function in children and young adults. This study assessed 415 healthy epsilon2 and epsilon4 carriers and matched epsilon3/epsilon3 controls, spanning ages 6-65, on a range of cognitive tests. Subjects were also compared on a new dynamical measure of EEG activity during a visual working memory task using alphabetical stimuli. epsilon4 subjects had better verbal fluency compared to epsilon3, an effect that was strongest in 51-65 year-olds. No epsilon4 deficits in cognition were found. In 6-15 year-olds, there were differences in total spatio-temporal wave activity between epsilon3 and epsilon4 subjects in the theta band, approximately 200ms post-stimulus. Differences in brain function in younger epsilon4 subjects and superior verbal fluency across the entire age range suggest that the APOE epsilon4 allele is an example of antagonistic pleiotropy. en_US
dc.publisher Elsevier Science Bv en_US
dc.relation.isbasedon en_US
dc.title The Contribution Of Apolipoprotein E Alleles On Cognitive Performance And Dynamic Neural Activity Over Six Decades en_US
dc.parent Biological Psychology en_US
dc.journal.volume 75 en_US
dc.journal.number 3 en_US
dc.publocation Amsterdam en_US
dc.identifier.startpage 229 en_US
dc.identifier.endpage 238 en_US FEIT.School of Systems, Management and Leadership en_US
dc.conference Verified OK en_US
dc.for 170200 en_US
dc.personcode 0000023008 en_US
dc.personcode 0000041646 en_US
dc.personcode 0000035782 en_US
dc.personcode 0000035783 en_US
dc.personcode 0000035784 en_US
dc.personcode 0000035785 en_US
dc.personcode 0000032240 en_US
dc.personcode 0000028514 en_US
dc.percentage 100 en_US Cognitive Sciences en_US
dc.classification.type FOR-08 en_US
dc.location.activity ISI:000248113400002 en_US
dc.description.keywords Traumatic Brain-injury; E Epsilon-4 Allele; Alzheimers-disease; E Polymorphism; E Genotype; Apoe Genotype; Lipoprotein Receptors; Memory Performance; Young-adults; Older Adults en_US
utslib.copyright.status Closed Access 2015-04-15 12:17:09.805752+10
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