Gold nanosphere-antibody conjugates for hyperthermal therapeutic applications

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Show simple item record Pissuwan, D Cortie, CH Valenzuela, SM Cortie, MB 2009-06-26T04:13:10Z 2007-07-04
dc.identifier.citation Gold Bulletin, 2007, 40 (2), pp. 121 - 129
dc.identifier.issn 0017-1557
dc.identifier.other C1 en_US
dc.description.abstract Gold nanoparticles can be conjugated with antibodies or other proteins, and the resulting composite particles will selectively attach to various kinds of biological material. Although exploitation of this for staining microscopy specimens is well known, there has recently been interest in attaching gold nanoparticles to live cells for therapeutic reasons. One motivation is that gold nanoparticles display a strong plasmon resonance with light, which can be exploited in principle for an 'in vivo' photothermal therapy. The treatment of cancer by this technique has recently received attention by others, but here we show how gold nanoparticle-based therapies can be developed to target live macrophage cells. We have employed 'active targeting', a scheme in which gold nanoparticles are functionalised with an antibody specific to the target macrophage cell. We describe how to prepare the conjugated particles, demonstrate that they will selectively attach 'in vitro' to their target macrophage cell but not to a non-target cell type and show that their presence renders the target cell susceptible to destruction by a low power laser.
dc.language eng
dc.title Gold nanosphere-antibody conjugates for hyperthermal therapeutic applications
dc.type Journal Article
dc.parent Gold Bulletin
dc.journal.volume 2
dc.journal.volume 40
dc.journal.number 2 en_US
dc.publocation UK en_US
dc.identifier.startpage 121 en_US
dc.identifier.endpage 129 en_US SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 0303 Macromolecular and Materials Chemistry
dc.for 0912 Materials Engineering
dc.personcode 020302
dc.personcode 010690
dc.personcode 102551
dc.percentage 50 en_US Materials Engineering en_US
dc.classification.type FOR-08 en_US
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - Health Technologies
utslib.copyright.status Open Access 2015-04-15 12:23:47.074767+10
pubs.consider-herdc true
utslib.collection.history School of Medical and Molecular Sciences (ID: 341)
utslib.collection.history General Collection (ID: 346) [2015-05-15T14:11:25+10:00]
utslib.collection.history General (ID: 2)

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