The integron/gene cassette system: an active player in bacterial adaptation

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dc.contributor.author Labbate, M
dc.contributor.author Case, RJ
dc.contributor.author Stokes, H
dc.contributor.editor Gogarten, M
dc.contributor.editor Gogarten, P
dc.contributor.editor Olendzenski, L
dc.date.accessioned 2010-05-28T09:38:36Z
dc.date.issued 2009-01
dc.identifier.citation Horizontal Gene Transfer, 2009, 1, pp. 103 - 125
dc.identifier.other B1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/7892
dc.description.abstract The integron includes a site-specific recombination system capable of integrating and expressing genes contained in structures called mobile gene cassettes. Integrons were originally identified on mobile elements from pathogenic bacteria and were found to be a major reservoir of antibiotic-resistance genes. Integrons are now known to be ancient structures that are phylogenetically diverse and, to date, have been found in approximately 9 % of sequenced bacterial genomes. Overall, gene diversity in cassettes is extraordinarily high suggesting that the integron/gene cassette system has a broad role in adaptation rather than being confined to simply conferring resistance to antibiotics. In this chapter, we provide a review of the integron/gene cassette system highlighting characteristics associated with this system, diversity of elements contained within it and their importance in driving bacterial evolution and consequently adaptation. Ideas on the evolution of gene cassettes and gene cassette arrays are discussed.
dc.publisher Humana Press
dc.relation.isbasedon 10.1007/978-1-60327-853-9
dc.title The integron/gene cassette system: an active player in bacterial adaptation
dc.type Chapter
dc.parent Horizontal Gene Transfer
dc.journal.number en_US
dc.publocation New York en_US
dc.publocation New York
dc.identifier.startpage 103 en_US
dc.identifier.endpage 125 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 0605 Microbiology
dc.personcode 106011
dc.personcode 105741
dc.percentage 100 en_US
dc.classification.name Gene and Molecular Therapy en_US
dc.classification.type FOR-08 en_US
dc.edition 1 en_US
dc.edition 1
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords Integron, gene cassette, antibiotic-resistance, attC
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - i3
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
pubs.consider-herdc false
utslib.collection.history Closed (ID: 3)
utslib.collection.history School of Medical and Molecular Sciences (ID: 341)
utslib.collection.history School of Medical and Molecular Sciences (ID: 341)


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