Salacia oblonga improves cardiac fibrosis and inhibits postprandial hyperglycemia in obese zucker rats

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dc.contributor.author Li, Y
dc.contributor.author Peng, G
dc.contributor.author Li, Q
dc.contributor.author Wen, S
dc.contributor.author Huang, TH
dc.contributor.author Roufogalis, BD
dc.contributor.author Yamahara, J
dc.date.accessioned 2009-06-26T04:22:41Z
dc.date.issued 2004-01
dc.identifier.citation Life Sciences, 2004, 75 (14), pp. 1735 - 1746
dc.identifier.issn 0024-3205
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/810
dc.description.abstract Diabetes has a markedly greater incidence of cardiovascular disease than the non-diabetic population. The heart shows a slowly developing increase in fibrosis in diabetes. Extended cardiac fibrosis results in increased myocardial stiffness, causing ventricular dysfunction and, ultimately, heart failure. Reversal of fibrosis may improve organ function survival. Postprandial hyperglycemia plays an important role in the development of type 2 diabetes and cardiovascular complications, and has been proposed as an independent risk factor for cardiovascular diseases. Salacia oblonga (S.O.) is traditionally used in the prevention and treatment of diabetes. We investigated the effects of its water extract on cardiac fibrosis and hyperglycemia in a genetic model of type 2 diabetes, the obese Zucker rat (OZR). Chronic administration of the extract markedly improved interstitial and perivascular fibrosis in the hearts of the OZR. It also reduced plasma glucose levels in non-fasted OZR, whereas it had little effect in the fasted animals, suggesting inhibition of postprandial hyperglycemia in type 2 diabetic animals, which might play a role in improvement of the cardiac complications of OZR. Furthermore, S.O. markedly suppressed the overexpression of mRNAs encoding transforming growth factor ?s 1 and 3 in the OZR heart, which may be an important part of the overall molecular mechanisms. S.O. dose-dependently inhibited the increase of plasma glucose in sucrose-, but not in glucose-loaded mice. S.O. demonstrated a strong inhibition of ?-glucosidase activity in vitro, which is suggested to contribute to the improvement of postprandial hyperglycemia.
dc.publisher Pergamon-Elsevier Science Ltd
dc.relation.isbasedon 10.1016/j.lfs.2004.04.013
dc.title Salacia oblonga improves cardiac fibrosis and inhibits postprandial hyperglycemia in obese zucker rats
dc.type Journal Article
dc.parent Life Sciences
dc.journal.volume 14
dc.journal.volume 75
dc.journal.number 14 en_US
dc.publocation Oxford, UK en_US
dc.identifier.startpage 1735 en_US
dc.identifier.endpage 1746 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 0601 Biochemistry and Cell Biology
dc.personcode 010344
dc.percentage 100 en_US
dc.classification.name Biochemistry and Cell Biology en_US
dc.classification.type FOR-08 en_US
dc.description.keywords Salacia oblonga; diabetes; heart; fibrosis; postprandial hyperglycemia en_US
dc.description.keywords Salacia oblonga
dc.description.keywords diabetes
dc.description.keywords heart
dc.description.keywords fibrosis
dc.description.keywords postprandial hyperglycemia
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
utslib.collection.history Uncategorised (ID: 363)
utslib.collection.history Closed (ID: 3)
utslib.collection.history General Collection (ID: 346) [2015-05-15T14:11:27+10:00]


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