Bromelain improves decrease in defecation in postoperative rats: modulation of colonic gene expression of inducible nitric oxide synthase

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dc.contributor.author Wen, S
dc.contributor.author Huang, TH
dc.contributor.author Li, GQ
dc.contributor.author Yamahara, J
dc.contributor.author Roufogalis, BD
dc.contributor.author Li, Y
dc.date.accessioned 2009-06-26T04:22:43Z
dc.date.issued 2006-01
dc.identifier.citation Life Sciences, 2006, 78 (9), pp. 995 - 1002
dc.identifier.issn 0024-3205
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/818
dc.description.abstract Ileus continues to be a common consequence of abdominal surgery, causing significant patient discomfort and often leading to more serious problems. The therapy available is limited, hence, ileus remains an important clinical problem. Activation of inducible nitric oxide synthase (iNOS) directly modulates intestinal dysmotility after bowel manipulation and plays an essential role in initiating intestinal inflammation. Nuclear factor (NF) kB i sknown to be a critical component of iNOS gene transcriptional activation in response to inflammatory stimuli. Bromlain is an crude extract from the pineapply stem, which is sold as a nutritional supplement to promote digestive health and as an anti-inflammatory medication in some developed countries. Here we have found that oral administration of bromelain improves decrease in defecation in abdominal postoperative rats. Results showed that bromelain increased wet weight, dry weight, water content and number of fecal pellets in laparotomised plus mechanically manipulated rats, suggetsing imporvement of postoperative ileus.
dc.publisher Elsevier
dc.relation.isbasedon 10.1016/j.lfs.2005.06.007
dc.title Bromelain improves decrease in defecation in postoperative rats: modulation of colonic gene expression of inducible nitric oxide synthase
dc.type Journal Article
dc.parent Life Sciences
dc.journal.volume 9
dc.journal.volume 78
dc.journal.number 9 en_US
dc.publocation USA en_US
dc.identifier.startpage 995 en_US
dc.identifier.endpage 1002 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 0601 Biochemistry and Cell Biology
dc.personcode 010344
dc.percentage 100 en_US
dc.classification.name Biochemistry and Cell Biology en_US
dc.classification.type FOR-08 en_US
dc.description.keywords Bromelain, Ileus, Defecation, Inducible nitric Oxide synthase, Nuclear factor-kB en_US
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
utslib.collection.history Uncategorised (ID: 363)
utslib.collection.history Closed (ID: 3)
utslib.collection.history General Collection (ID: 346) [2015-05-15T14:11:28+10:00]


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