Analysis of antimalarial synergy between bestatin and endoprotease inhibitors using statistical response-surface modelling.

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dc.contributor.author Gavigan, CS
dc.contributor.author Machado, SG
dc.contributor.author Dalton, JP
dc.contributor.author Bell, A
dc.date.accessioned 2010-05-28T09:44:16Z
dc.date.issued 2001-11
dc.identifier.citation Antimicrobial agents and chemotherapy, 2001, 45 (11), pp. 3175 - 3181
dc.identifier.issn 0066-4804
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/8588
dc.description.abstract The pathway of hemoglobin degradation by erythrocytic stages of the human malarial parasite Plasmodium falciparum involves initial cleavages of globin chains, catalyzed by several endoproteases, followed by liberation of amino acids from the resulting peptides, probably by aminopeptidases. This pathway is considered a promising chemotherapeutic target, especially in view of the antimalarial synergy observed between inhibitors of aspartyl and cysteine endoproteases. We have applied response-surface modelling to assess antimalarial interactions between endoprotease and aminopeptidase inhibitors using cultured P. falciparum parasites. The synergies observed were consistent with a combined role of endoproteases and aminopeptidases in hemoglobin catabolism in this organism. As synergies between antimicrobial agents are often inferred without proper statistical analysis, the model used may be widely applied in studies of antimicrobial drug interactions.
dc.format Print
dc.language eng
dc.relation.isbasedon 10.1128/aac.45.11.3175-3181.2001
dc.title Analysis of antimalarial synergy between bestatin and endoprotease inhibitors using statistical response-surface modelling.
dc.type Journal Article
dc.parent Antimicrobial agents and chemotherapy
dc.journal.volume 11
dc.journal.volume 45
dc.journal.number 11 en_US
dc.publocation Washington, USA en_US
dc.identifier.startpage 3175 en_US
dc.identifier.endpage 3181 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 0605 Microbiology
dc.personcode 030896
dc.percentage 100 en_US
dc.classification.name Microbiology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.location.activity ISI:000185710300007
dc.description.keywords Animals
dc.description.keywords Plasmodium falciparum
dc.description.keywords Pepstatins
dc.description.keywords Protease Inhibitors
dc.description.keywords Drug Synergism
dc.description.keywords Leucine
dc.description.keywords Antimalarials
dc.description.keywords Algorithms
dc.description.keywords Models, Biological
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
pubs.consider-herdc false
utslib.collection.history Closed (ID: 3)


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