ABC transporters: a riddle wrapped in a mystery inside an enigma

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dc.contributor.author Jones, PM
dc.contributor.author O'Mara, ML
dc.contributor.author George, AM
dc.date.accessioned 2010-05-28T09:44:47Z
dc.date.issued 2009-10
dc.identifier.citation Trends in Biochemical Sciences, 2009, 34 (10), pp. 520 - 531
dc.identifier.issn 0968-0004
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/8676
dc.description.abstract ATP-binding cassette (ABC) transporters form one of the largest and most ancient of protein families. ABC transporters couple hydrolysis of ATP to vectorial translocation of diverse substrates across cellular membranes. Many human ABC transporters are medically important in causing, for example, multidrug resistance to cytotoxic drugs. Seven complete prokaryotic structures and one eukaryotic structure have been solved for transporters from 2002 to date, and a wealth of research is being conducted on and around these structures to resolve the mechanistic conundrum of how these transporters couple ATP hydrolysis in cytosolic domains to substrate translocation through the transmembrane pore. Many questions remained unanswered about this mechanism, despite a plethora of data and a number of interesting and controversial models. © 2009 Elsevier Ltd. All rights reserved.
dc.language eng
dc.relation.hasversion Accepted manuscript version en_US
dc.relation.isbasedon 10.1016/j.tibs.2009.06.004
dc.rights NOTICE: this is the author’s version of a work that was accepted for publication in Trends in Biochemical Sciences. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Trends in Biochemical Sciences, [VOL 34, (2009)] DOI: http://dx.doi.org/10.1016/j.tibs.2009.06.004 en_US
dc.title ABC transporters: a riddle wrapped in a mystery inside an enigma
dc.type Journal Article
dc.parent Trends in Biochemical Sciences
dc.journal.volume 10
dc.journal.volume 34
dc.journal.number en_US
dc.journal.number 10 en_US
dc.publocation Cambridge, MA, USA en_US
dc.identifier.startpage 520 en_US
dc.identifier.endpage 531 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 0601 Biochemistry and Cell Biology
dc.for 0903 Biomedical Engineering
dc.personcode 020174
dc.personcode 860231
dc.percentage 67 en_US
dc.classification.name Biomedical Engineering en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords NA en_US
dc.description.keywords NA
dc.description.keywords NA
dc.description.keywords NA
dc.description.keywords Humans
dc.description.keywords Molybdenum
dc.description.keywords Metals
dc.description.keywords Maltose
dc.description.keywords Methionine
dc.description.keywords ATP-Binding Cassette Transporters
dc.description.keywords Adenosine Triphosphate
dc.description.keywords Crystallography, X-Ray
dc.description.keywords Evolution, Molecular
dc.description.keywords Binding Sites
dc.description.keywords Protein Conformation
dc.description.keywords Biological Transport
dc.description.keywords Models, Molecular
dc.description.keywords Humans
dc.description.keywords Molybdenum
dc.description.keywords Metals
dc.description.keywords ATP-Binding Cassette Transporters
dc.description.keywords Adenosine Triphosphate
dc.description.keywords Maltose
dc.description.keywords Crystallography, X-Ray
dc.description.keywords Evolution, Molecular
dc.description.keywords Protein Conformation
dc.description.keywords Biological Transport
dc.description.keywords Binding Sites
dc.description.keywords Methionine
dc.description.keywords Models, Molecular
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Faculty of Science/School of Medical and Molecular Sciences
pubs.organisational-group /University of Technology Sydney/Strength - i3
utslib.copyright.status Open Access
utslib.copyright.date 2015-04-15 12:23:47.074767+10


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