Alterations of the Birt-Hogg-Dube gene (BHD) in sporadic colorectal tumours

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dc.contributor.author Kahnoski, K
dc.contributor.author Khoo, SK
dc.contributor.author Nassif, N
dc.contributor.author Chen, J
dc.contributor.author Lobo, GP
dc.contributor.author Segelov, E
dc.contributor.author Teh, BT
dc.date.accessioned 2010-05-28T09:44:49Z
dc.date.issued 2003-01
dc.identifier.citation Journal of Medical Genetics, 2003, 40 (7), pp. 511 - 515
dc.identifier.issn 1468-6244
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/8683
dc.description.abstract Colorectal cancer (CRC) is the third most common cancer diagnosed in both men and women, and the second most common cause of cancer deaths in the United States. There were approximately 150 000 new cases resulting in 57 000 deaths in 2002.1 CRC is one of the most studied cancer types and its underlying aetiology best, elucidated. Colorectal tumorigenesis involves a multistep process including genetic and epigenetic alterations of numerous CRC related genes that may act as either oncogenes or tumour suppressor genes.2-5 The majority of sporadic CRCs are characterised by deletions of large chromosomal segments, which are thought to represent the loss of wild type tumour suppressor genes.6 7 About 15% of sporadic CRCs, on the other hand, show microsatellite instability (MSI), characterised by the insertion and/or deletion of simple repeat sequences and indicative of the involvement of defective mismatch repair.
dc.publisher BMJ Publishing Group Ltd
dc.relation.hasversion Accepted manuscript version en_US
dc.title Alterations of the Birt-Hogg-Dube gene (BHD) in sporadic colorectal tumours
dc.type Journal Article
dc.parent Journal of Medical Genetics
dc.journal.volume 7
dc.journal.volume 40
dc.journal.number 7 en_US
dc.publocation UK en_US
dc.identifier.startpage 511 en_US
dc.identifier.endpage 515 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 060405 Gene Expression (Incl. Microarray and Other Genome-Wide Approaches)
dc.personcode 030580
dc.percentage 100 en_US
dc.classification.name Gene Expression (incl. Microarray and other genome-wide approaches) en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - Health Technologies
utslib.copyright.status Open Access
utslib.copyright.date 2015-04-15 12:23:47.074767+10
pubs.consider-herdc false
utslib.collection.history School of Medical and Molecular Sciences (ID: 341)
utslib.collection.history School of Medical and Molecular Sciences (ID: 341)
utslib.collection.history General (ID: 2)


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