Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

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dc.contributor.author Kennedy, MK
dc.contributor.author Glaccum, M
dc.contributor.author Brown, SN
dc.contributor.author Butz, EA
dc.contributor.author Viney, JL
dc.contributor.author Embers, M
dc.contributor.author Matsuki, N
dc.contributor.author Charrier, K
dc.contributor.author Sedger, LM
dc.contributor.author Willis, CR
dc.contributor.author Brasel, K
dc.contributor.author Morrissey, PJ
dc.contributor.author Stocking, K
dc.contributor.author Schuh, JC
dc.contributor.author Joyce, S
dc.contributor.author Peschon, JJ
dc.date.accessioned 2010-05-28T09:44:50Z
dc.date.issued 2000-01
dc.identifier.citation Journal Of Experimental Medicine, 2000, 191 (5), pp. 771 - 780
dc.identifier.issn 0022-1007
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/8687
dc.description.abstract C57BL/6 mice genetically deficient in interleukin 15 (IL-15(-/-) mice) were generated by gene targeting. IL-15(-/-) mice displayed marked reductions in numbers of thymic and peripheral natural killer (NK) T cells, memory phenotype CD8(+) T cells, and distinct subpopulations of intestinal intraepithelial lymphocytes (IELs). The reduction but not absence of these populations in IL-15(-/-) mice likely reflects all important role for IL-15 for expansion and/or survival of these cells. IL-15(-/-) mice lacked NK cells, as assessed by both immunophenotyping and functional criteria, indicating an obligate role for IL-15 in the development and functional maturation of NK cells. Specific defects associated with IL-15 deficiency were reversed by in vivo administration of exogenous IL-15. Despite their immunological defects, IL-15(-/-) mice remained healthy when maintained under specific pathogen-free conditions. However, IL-15(-/-) mice are likely to have compromised host defense responses to various pathogens, as they were unable to mount a protective response to challenge with vaccinia virus. These data reveal critical roles for IL-15 in the development of specific lymphoid lineages. Moreover, the ability to rescue lymphoid defects in IL-15(-/-) mice by IL-15 administration represents a powerful means by which to further elucidate the biological roles of this cytokine.
dc.format Esha Dutt
dc.publisher Rockefeller Univ Press
dc.relation.isbasedon 10.1084/jem.191.5.771
dc.title Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
dc.type Journal Article
dc.parent Journal Of Experimental Medicine
dc.journal.volume 5
dc.journal.volume 191
dc.journal.number 5 en_US
dc.publocation New York, USA en_US
dc.identifier.startpage 771 en_US
dc.identifier.endpage 780 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 060103 Cell Development, Proliferation and Death
dc.for 060506 Virology
dc.personcode 102397
dc.percentage 60 en_US
dc.classification.name Virology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity ISI:000085810000004 en_US
dc.location.activity ISI:000085810000004
dc.location.activity ISI:000085810000004
dc.location.activity ISI:000085810000004
dc.location.activity ISI:000085810000004
dc.description.keywords interleukin 15; knockout mice; natural killer cells; CD8(+) T lymphocytes; immunologic memory en_US
dc.description.keywords interleukin 15
dc.description.keywords interleukin 15
dc.description.keywords knockout mice
dc.description.keywords knockout mice
dc.description.keywords natural killer cells
dc.description.keywords natural killer cells
dc.description.keywords CD8(+) T lymphocytes
dc.description.keywords CD8(+) T lymphocytes
dc.description.keywords immunologic memory
dc.description.keywords immunologic memory
dc.description.keywords interleukin 15
dc.description.keywords knockout mice
dc.description.keywords natural killer cells
dc.description.keywords CD8(+) T lymphocytes
dc.description.keywords immunologic memory
dc.description.keywords interleukin 15
dc.description.keywords knockout mice
dc.description.keywords natural killer cells
dc.description.keywords CD8(+) T lymphocytes
dc.description.keywords immunologic memory
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science


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