Searching for new markers of endogenous steroid administration in athletes: looking outside the metabolic box

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dc.contributor.author Cawley, A
dc.contributor.author Hine, ER
dc.contributor.author Trout, GJ
dc.contributor.author George, AV
dc.contributor.author Kazlauskas, R
dc.date.accessioned 2009-08-20T13:01:26Z
dc.date.issued 2004-01
dc.identifier.citation Forensic Science International, 2004, 143 (2), pp. 103 - 114
dc.identifier.issn 0379-0738
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/868
dc.description.abstract A simple means of detecting the abuse of steroids that also occur naturally is a problem facing doping control laboratories. Specific markers are required to allow the detection of the administration of these steroids. These markers are commonly measured using a set of data obtained from the screening of samples by gas chromatographymass spectrometry (GCMS). Doping control laboratories further need to confirm identified abuse using techniques such as gas chromatographycombustionisotope ratio mass spectrometry (GCCIRMS). An interesting urinary species was found while following the pharmacokinetics and changes to the steroid profile from single and multiple oral doses of the International Olympic Committee/World Anti Doping Agency (IOC/WADA) prohibited substance, dehydroepiandrosterone (DHEA). The urine samples collected from the administration studies were subject to GCMS and GCCIRMS steroid analysis following cleanup by solid phase extraction techniques. A useful urinary product of DHEA administration was detected in the urine samples from each of the administration studies and was identified by GCMS experiments to be 3?,5-cyclo-5?-androstan-6?-ol-17-one (3?,5-cyclo). This compound occurs naturally but the concentrations of 3?,5-cyclo were elevated following both the single DHEA administration (up to 385ng/mL) and multiple DHEA administrations (up to 1240ng/mL), in relation to those observed prior to these administrations (70 and 80ng/mL, respectively).
dc.publisher Elsevier Sci Ireland Ltd
dc.relation.isbasedon 10.1016/j.forsciint.2004.02.031
dc.title Searching for new markers of endogenous steroid administration in athletes: looking outside the metabolic box
dc.type Journal Article
dc.parent Forensic Science International
dc.journal.volume 2
dc.journal.volume 143
dc.journal.number 2-3 en_US
dc.publocation Clare en_US
dc.identifier.startpage 103 en_US
dc.identifier.endpage 114 en_US
dc.cauo.name Science en_US
dc.personcode 99067035
dc.personcode 121550
dc.description.keywords Doping control, Endogenous steroids, Dehydroepiandrosterone (DHEA), Gas chromatographymass spectrometry, Gas chromatographycombustionisotope ratio mass spectrometry, 3?,5-Cyclo-5?-androstan-6?-ol-17-one (3?,5-cyclo)
dc.description.keywords Doping control, Endogenous steroids, Dehydroepiandrosterone (DHEA), Gas chromatographymass spectrometry, Gas chromatographycombustionisotope ratio mass spectrometry, 3?,5-Cyclo-5?-androstan-6?-ol-17-one (3?,5-cyclo)
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
utslib.copyright.date 2015-04-15 12:17:09.805752+10
pubs.consider-herdc true
pubs.consider-herdc true
utslib.collection.history Closed (ID: 3)
utslib.collection.history General Collection (ID: 346) [2015-05-15T14:11:29+10:00]


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