Immunological interactions between 2common pathogens, the Th1-inducing protozoan Toxoplasma gondii and the Th2-inducing helminth Fasciola hepatica

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dc.contributor.author Miller, CM
dc.contributor.author Smith, NC
dc.contributor.author Ikin, RJ
dc.contributor.author Boulter, N
dc.contributor.author Dalton, JP
dc.contributor.author Donnelly, SM
dc.date.accessioned 2010-05-28T09:45:05Z
dc.date.issued 2009-01
dc.identifier.citation PLoS ONE, 2009, 4 (5), pp. 1 - 10
dc.identifier.issn 1932-6203
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/8727
dc.description.abstract The nature of the immune response to infection is dependent on the type of infecting organism. Intracellular organisms such as Toxoplasma gondii stimulate a Th1-driven response associated with production of IL-12, IFN-?, nitric oxide and IgG2a antibodies and classical activation of macrophages. In contrast, extracellular helminths such as Fasciola hepatica induce Th2 responses characterised by the production of IL-4, IL-5, IL-10 and IgG1 antibodies and alternative activation of macrophages. As co-infections with these types of parasites commonly exist in the field it is relevant to examine how the various facets of the immune responses induced by each may influence or counter-regulate that of the other.
dc.publisher Public Library of Science
dc.title Immunological interactions between 2common pathogens, the Th1-inducing protozoan Toxoplasma gondii and the Th2-inducing helminth Fasciola hepatica
dc.type Journal Article
dc.parent PLoS ONE
dc.journal.volume 5
dc.journal.volume 4
dc.journal.number 5 en_US
dc.publocation USA en_US
dc.identifier.startpage 1 en_US
dc.identifier.endpage 10 en_US
dc.cauo.name SCI.Institute for Biotechnology of Infectious Diseases en_US
dc.conference Verified OK en_US
dc.for 0707 Veterinary Sciences
dc.personcode 960087
dc.personcode 011172
dc.personcode 995261
dc.personcode 030896
dc.personcode 970043
dc.personcode 103482
dc.percentage 100 en_US
dc.classification.name Veterinary Sciences en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - i3
utslib.copyright.status Open Access
utslib.copyright.date 2015-04-15 12:23:47.074767+10
pubs.consider-herdc true
utslib.collection.history School of Medical and Molecular Sciences (ID: 341)
utslib.collection.history General (ID: 2)


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