Quorum sensing-controlled biofilm development in Serratia liquefaciens MG1.

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dc.contributor.author Labbate, M
dc.contributor.author Queck, SY
dc.contributor.author Koh, KS
dc.contributor.author Rice, SA
dc.contributor.author Givskov, M
dc.contributor.author Kjelleberg, S
dc.date.accessioned 2010-05-28T09:45:14Z
dc.date.issued 2004-02
dc.identifier.citation Journal of bacteriology, 2004, 186 (3), pp. 692 - 698
dc.identifier.issn 0021-9193
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/8749
dc.description.abstract Serratia liquefaciens MG1 contains an N-acylhomoserine lactone-mediated quorum-sensing system that is known to regulate swarming motility colonization. In this study, we describe for S. liquefaciens MG1 the development of a novel biofilm consisting of cell aggregates and differentiated cell types, such as cell chains and long filamentous cells. Furthermore, quorum sensing is shown to be crucial for normal biofilm development and for elaborate differentiation. A mutant of S. liquefaciens MG1 that was incapable of synthesizing extracellular signal formed a thin and nonmature biofilm lacking cell aggregates and differentiated cell chains. Signal-based complementation of this mutant resulted in a biofilm with the wild-type architecture. Two quorum-sensing-regulated genes (bsmA and bsmB) involved in biofilm development were identified, and we propose that these genes are engaged in fine-tuning the formation of cell aggregates at a specific point in biofilm development.
dc.format Print
dc.language eng
dc.relation.isbasedon 10.1128/jb.186.3.692-698.2004
dc.title Quorum sensing-controlled biofilm development in Serratia liquefaciens MG1.
dc.type Journal Article
dc.parent Journal of bacteriology
dc.journal.volume 3
dc.journal.volume 186
dc.journal.number en_US
dc.publocation Washington DC, USA en_US
dc.identifier.startpage 692 en_US
dc.identifier.endpage 698 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 060503 Microbial Genetics
dc.personcode 106011
dc.percentage 100 en_US
dc.classification.name Microbial Genetics en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.location.activity United States
dc.description.keywords NA en_US
dc.description.keywords NA
dc.description.keywords 4-Butyrolactone
dc.description.keywords Biofilms
dc.description.keywords Serratia liquefaciens
dc.description.keywords Biofilms
dc.description.keywords Serratia liquefaciens
dc.description.keywords 4-Butyrolactone
dc.description.keywords Biofilms
dc.description.keywords Biofilms
dc.description.keywords Serratia liquefaciens
dc.description.keywords Serratia liquefaciens
dc.description.keywords 4-Butyrolactone
dc.description.keywords 4-Butyrolactone
dc.description.keywords Biofilms
dc.description.keywords Serratia liquefaciens
dc.description.keywords 4-Butyrolactone
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Faculty of Science/School of Medical and Molecular Sciences
pubs.organisational-group /University of Technology Sydney/Strength - i3
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10


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