An open-loop model for investigating mammalian thermosensitivity

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Show simple item record Gordon, C Haley, CD McLennan, PL Tipton, MJ MekjaviĿ, IB Taylor, NA 2010-05-28T09:45:21Z 2004-01
dc.identifier.citation Journal of Thermal Biology, 2004, 29 (7-8), pp. 703 - 707
dc.identifier.issn 0306-4565
dc.identifier.other C1UNSUBMIT en_US
dc.description.abstract We have developed, and herein describe, a simple, open-loop model in the rat, in which both skin and hypothalamic temperatures can be modified and clamped. A water-perfused thermode was positioned in the abdomen to drive hypothalamic temperature, and a water-perfused jacket was used to clamp skin temperature. These permitted the independent control of hypothalamic and skin temperatures. The former could be altered between 35 and 41 °C whilst achieving an isothermal skin temperature clamp. Similarly, skin temperature could be modified between 22 and 42 °C whilst hypothalamic temperature was clamped. Maximal hypothalamic heating and cooling rates were: 0.75 and -2.04 °C h-1 100 g-1. We are currently using this animal model to investigate how central thermosensitivity is affected via manipulations of hypothalamic cooling rates.
dc.publisher Elsevier
dc.relation.isbasedon 10.1016/j.jtherbio.2004.08.043
dc.title An open-loop model for investigating mammalian thermosensitivity
dc.type Journal Article
dc.parent Journal of Thermal Biology
dc.journal.volume 7-8
dc.journal.volume 29
dc.journal.number 7-8 en_US
dc.publocation Devon, UK en_US
dc.identifier.startpage 703 en_US
dc.identifier.endpage 707 en_US FOH.Faculty of Health en_US
dc.conference Verified OK en_US
dc.for 060802 Animal Cell and Molecular Biology
dc.personcode 044077
dc.percentage 100 en_US Animal Cell and Molecular Biology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US en_US
dc.location.activity en_US
dc.description.keywords Body temperature regulation; Core temperature; Model; Skin temperature; Threshold; Rats en_US
dc.description.keywords Body temperature regulation
dc.description.keywords Core temperature
dc.description.keywords Model
dc.description.keywords Skin temperature
dc.description.keywords Threshold
dc.description.keywords Rats
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Health
utslib.copyright.status Closed Access 2015-04-15 12:17:09.805752+10
utslib.collection.history Closed (ID: 3)

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