Optical endpoint sensing in an automatic whole blood clotting timer

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dc.contributor.author Bertram, CD
dc.contributor.author Milthorpe, BK
dc.date.accessioned 2010-05-28T09:47:58Z
dc.date.issued 1984-09
dc.identifier.citation Medical and Biological Engineering and Computing, 1984, 22 (5), pp. 401 - 405
dc.identifier.issn 0140-0118
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/9177
dc.description.abstract Most clotting time estimations are performed manually, although attempts have been made previously to automate them. The two major methods for automatically detecting the formation of the gel-like clot are mechanical (viscometric) and optical. The latter is superior in terms of accuracy of timing and freedom from artefacts but can only be performed on blood plasma. This paper describes a device which combines centrifuging to remove red cells and optical sensing of clot formation into a single operation, thereby giving activated clotting times on a par with those obtained mechanically from whole blood. The system offers the advantage over mechanical sensing that no nondisposable parts come in contact with the blood, thereby eliminating a major source of timing errors. The timer works with any liquid coagulation activator, and will also time plasma clotting. The two-chambered design of the cuvette allows the activator to be kept separate from the blood until rotor startup. The start of centrifugal action mixes the blood and activator and starts the timer. Timing is stopped automatically when the rate of increase of optical density in the plasma, owing to fibrin formation, reaches a predetermined level.
dc.language eng
dc.title Optical endpoint sensing in an automatic whole blood clotting timer
dc.type Journal Article
dc.parent Medical and Biological Engineering and Computing
dc.journal.volume 5
dc.journal.volume 22
dc.journal.number en_US
dc.publocation Germany en_US
dc.identifier.startpage 401 en_US
dc.identifier.endpage 405 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 090303 Biomedical Instrumentation
dc.personcode 105631
dc.percentage 100 en_US
dc.classification.name Biomedical Instrumentation en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - Health Technologies
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
pubs.consider-herdc false
utslib.collection.history Closed (ID: 3)

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