Analysis of 3D bone ingrowth into polymer scaffolds via micro-computed tomography imaging

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dc.contributor.author Jones, AC
dc.contributor.author Milthorpe, B
dc.contributor.author Averdunk, H
dc.contributor.author Limaye, A
dc.contributor.author Senden, TJ
dc.contributor.author Sakellariou, A
dc.contributor.author Sheppard, AP
dc.contributor.author Sok, RM
dc.contributor.author Knackstedt, MA
dc.contributor.author Brandwood, A
dc.contributor.author Rohner, D
dc.contributor.author Hutmacher, DW
dc.date.accessioned 2010-05-28T09:48:27Z
dc.date.issued 2004-09
dc.identifier.citation Biomaterials, 2004, 25 (20), pp. 4947 - 4954
dc.identifier.issn 0142-9612
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/9258
dc.description.abstract This paper illustrates the utility of micro-computed tomography (micro-CT) to study the process of tissue engineered bone growth. A micro-CT facility for imaging and visualising biomaterials in three dimensions (3D) is described. The facility is capable of acquiring 3D images made up of 20003 voxels on specimens up to 60mm in extent with resolutions down to 2μm. This allows the 3D structure of tissue engineered materials to be imaged across three orders of magnitude of detail. The capabilities of micro-CT are demonstrated by imaging the Haversian network within human femoral cortical bone (distal diaphysis) and bone ingrowth into a porous scaffold at varying resolutions. Phase identification combined with 3D visualisation enables one to observe the complex topology of the canalicular system of the cortical bone. Imaging of the tissue engineered bone at a scale of 1cm and resolutions of 10μm allows visualisation of the complex ingrowth of bone into the polymer scaffold. Further imaging at 2μm resolution allows observation of bone ultra-structure. These observations illustrate the benefits of tomography over traditional techniques for the characterisation of bone morphology and interconnectivity and performs a complimentary role to current histomorphometric techniques. © 2004 Elsevier Ltd. All rights reserved.
dc.language eng
dc.relation.isbasedon 10.1016/j.biomaterials.2004.01.047
dc.title Analysis of 3D bone ingrowth into polymer scaffolds via micro-computed tomography imaging
dc.type Journal Article
dc.parent Biomaterials
dc.journal.volume 20
dc.journal.volume 25
dc.journal.number 20 en_US
dc.publocation Oxford, UK en_US
dc.identifier.startpage 4947 en_US
dc.identifier.endpage 4954 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 0903 Biomedical Engineering
dc.personcode 105631
dc.percentage 100 en_US
dc.classification.name Biomedical Engineering en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords Bone tissue engineering
dc.description.keywords Image analysis
dc.description.keywords Micro-structure
dc.description.keywords Scaffold
dc.description.keywords X-ray micro-computed tomography
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - Health Technologies
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
pubs.consider-herdc false
utslib.collection.history Closed (ID: 3)


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